Academic Journal
Transcatheter edge to edge repair of functional mitral regurgitation as bridge to heart transplantation: 2-years follow up results from MitraBridge international registry
| العنوان: | Transcatheter edge to edge repair of functional mitral regurgitation as bridge to heart transplantation: 2-years follow up results from MitraBridge international registry |
|---|---|
| المؤلفون: | Marcelli, C, Munafo', A R, Estevez-Loureiro, R, Adamo, M, Guerin, P, Arzamendi, D, Ho, E C, Asgar, A, Petronio, A S, Grasso, C, Van Mieghem, N M, Tarantini, G, Potena, L, Saia, F, Godino, C |
| المصدر: | European Heart Journal ; volume 44, issue Supplement_2 ; ISSN 0195-668X 1522-9645 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2023 |
| الوصف: | Background Chronic severe functional mitral regurgitation (FMR) is a common finding in patients with advanced heart failure (AHF) who undergo evaluation for heart transplantation (HTx). Nevertheless, access to surgical strategies for AHF could be limited by scarce availability of donors and by temporary or definitive contraindications. MitraBridge registry already proved that transcatheter edge to edge repair (TEER) of FMR performed as a bridge to HTx is an effective and safe treatment strategy at 1-year follow up with 64% of patients free from composite primary endpoint of all-cause death, new admission for HF, urgent HTx or LVAD implantation. Purpose The aim of this study is to determine whether 1-year results of MitraBridge registry were maintained at 2-years follow up. Methods Mitrabridge is a retrospective, multicenter observational study that enrolled 153 adult patients with AHF and moderate-to-severe or severe FMR and considered candidates for HTx who underwent TEER between 2018 and 2021. Depending on the strategy TEER was performed for, patients were classified in bridge to transplant, candidacy or decision. Primary endpoint of the current analysis was the 2-year composite rate of all-cause death, new admission for HF, urgent HTx or LVAD implantation. Results Median age was 59 years old [53-63], most patients were in INTERMACS class 5-6 (47.5%) and mean left ventricle ejection fraction (LVEF) was 26.9±7.7%. Baseline right heart catheterization was available for 112 (73%) patients, of them 87.5% had pulmonary hypertension with mean pulmonary artery pressure (mPAP) of 33±10 mmHg. Procedural success was achieved in 89.5% of cases and no deaths at 30 days were reported. At 2-years follow up, freedom from primary endpoint was maintained in 47% of patients. A significant reduction of echocardiographic systolic pulmonary artery pressure (sPAP) was observed (from 50 [40-61] mmHg to 43 [33-53] mmHg, p-value<0.001). At the end of follow-up (median time of 26 months, IQR 9-52), elective HTx was ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/eurheartj/ehad655.1135 |
| الاتاحة: | https://doi.org/10.1093/eurheartj/ehad655.1135 https://academic.oup.com/eurheartj/article-pdf/44/Supplement_2/ehad655.1135/53592850/ehad655.1135.pdf |
| Rights: | https://academic.oup.com/pages/standard-publication-reuse-rights |
| رقم الانضمام: | edsbas.216579DD |
| قاعدة البيانات: | BASE |
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