Academic Journal
High-speed video gait analysis reveals early and characteristic locomotor phenotypes in mouse models of neurodegenerative movement disorders
| العنوان: | High-speed video gait analysis reveals early and characteristic locomotor phenotypes in mouse models of neurodegenerative movement disorders |
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| المؤلفون: | Preisig, Daniel F, Kulic, Luka, Krüger, Maik, Wirth, Fabian, McAfoose, Jordan, Späni, Claudia, Gantenbein, Pascal, Derungs, Rebecca, Nitsch, Roger M, Welt, Tobias |
| المصدر: | Preisig, Daniel F; Kulic, Luka; Krüger, Maik; Wirth, Fabian; McAfoose, Jordan; Späni, Claudia; Gantenbein, Pascal; Derungs, Rebecca; Nitsch, Roger M; Welt, Tobias (2016). High-speed video gait analysis reveals early and characteristic locomotor phenotypes in mouse models of neurodegenerative movement disorders. Behavioural Brain Research, 311:340-353. |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2016 |
| المجموعة: | University of Zurich (UZH): ZORA (Zurich Open Repository and Archive |
| مصطلحات موضوعية: | Institute for Regenerative Medicine (IREM), 610 Medicine & health |
| الوصف: | Neurodegenerative diseases of the central nervous system frequently affect the locomotor system resulting in impaired movement and gait. In this study we performed a whole-body high-speed video gait analysis in three different mouse lines of neurodegenerative movement disorders to investigate the motor phenotype. Based on precise computerized motion tracking of all relevant joints and the tail, a custom-developed algorithm generated individual and comprehensive locomotor profiles consisting of 164 spatial and temporal parameters. Gait changes observed in the three models corresponded closely to the classical clinical symptoms described in these disorders: Muscle atrophy due to motor neuron loss in SOD1 G93A transgenic mice led to gait characterized by changes in hind-limb movement and positioning. In contrast, locomotion in huntingtin N171-82Q mice modeling Huntington's disease with basal ganglia damage was defined by hyperkinetic limb movements and rigidity of the trunk. Harlequin mutant mice modeling cerebellar degeneration showed gait instability and extensive changes in limb positioning. Moreover, model specific gait parameters were identified and were shown to be more sensitive than conventional motor tests. Altogether, this technique provides new opportunities to decipher underlying disease mechanisms and test novel therapeutic approaches. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0166-4328 |
| Relation: | https://www.zora.uzh.ch/130307; info:pmid/27233823; urn:issn:0166-4328 |
| DOI: | 10.1016/j.bbr.2016.04.044 |
| الاتاحة: | https://www.zora.uzh.ch/id/eprint/130307/ https://www.zora.uzh.ch/130307 https://doi.org/10.1016/j.bbr.2016.04.044 |
| Rights: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.215BE53E |
| قاعدة البيانات: | BASE |
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