Academic Journal
Aortic valve calcification is promoted by interleukin-8 and restricted through antagonizing CXC motif chemokine receptor 2
| العنوان: | Aortic valve calcification is promoted by interleukin-8 and restricted through antagonizing CXC motif chemokine receptor 2 |
|---|---|
| المؤلفون: | Dhayni, Kawthar, Chabry, Yuthiline, Hénaut, Lucie, Avondo, Carine, Boudot, Cedric, Ouled-Haddou, Hakim, Bigot-Corbel, Edith, Touati, Gilles, Caus, Thierry, Messaoudi, Hind, Bellien, Jérémy, Tribouilloy, Christophe, Messika-Zeitoun, David, Zibara, Kazem, Kamel, Saïd, Bennis, Youssef |
| المساهمون: | University Hospital, Cardiac Research Network, Aortic VAlve, French Government, National Research Agency |
| المصدر: | Cardiovascular Research ; volume 119, issue 13, page 2355-2367 ; ISSN 0008-6363 1755-3245 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2023 |
| الوصف: | Aims Inflammatory cytokines play a critical role in the progression of calcific aortic valve disease (CAVD), for which there is currently no pharmacological treatment. The aim of this study was to test the hypothesis that interleukin-8 (IL-8), known to be involved in arterial calcification, also promotes aortic valve calcification (AVC) and to evaluate whether pharmacologically blocking the IL-8 receptor, CXC motif chemokine receptor 2 (CXCR2), could be effective in preventing AVC progression. Methods and results A cohort of 195 patients (median age 73, 74% men) diagnosed with aortic valve stenosis (severe in 16.9% of cases) were prospectively followed by CT for a median time of 2.6 years. A Cox proportional hazards regression analysis indicated that baseline IL-8 serum concentrations were associated with rapid progression of AVC, defined as an annualized change in the calcification score by CT ≥ 110 AU/year, after adjustment for age, gender, bicuspid anatomy, and baseline disease severity. In vitro, exposure of primary human aortic valvular interstitial cells (hVICs) to 15 pg/mL IL-8 induced a two-fold increase in inorganic phosphate (Pi)-induced calcification. IL-8 promoted NFκB pathway activation, MMP-12 expression, and elastin degradation in hVICs exposed to Pi. These effects were prevented by SCH527123, an antagonist of CXCR2. The expression of CXCR2 was confirmed in hVICs and samples of aortic valves isolated from patients with CAVD, in which the receptor was mainly found in calcified areas, along with MMP-12 and a degraded form of elastin. Finally, in a rat model of chronic kidney disease-associated CAVD, SCH527123 treatment (1 mg/kg/day given orally for 11 weeks) limited the decrease in aortic cusp separation, the increase in maximal velocity of the transaortic jet, and the increase in aortic mean pressure gradient measured by echocardiography, effects that were associated with a reduction in hydroxyapatite deposition and MMP-12 expression in the aortic valves. Conclusion Overall, these results ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/cvr/cvad117 |
| DOI: | 10.1093/cvr/cvad117/51090218/cvad117.pdf |
| الاتاحة: | https://doi.org/10.1093/cvr/cvad117 https://academic.oup.com/cardiovascres/advance-article-pdf/doi/10.1093/cvr/cvad117/51090218/cvad117.pdf https://academic.oup.com/cardiovascres/article-pdf/119/13/2355/52460121/cvad117.pdf |
| Rights: | https://academic.oup.com/pages/standard-publication-reuse-rights |
| رقم الانضمام: | edsbas.1B251BD4 |
| قاعدة البيانات: | BASE |
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