Two immunomodulators, curcumin and sulfasalazine, enhance IDV antiretroviral activity in HIV-1 persistently infected cells
العنوان: | Two immunomodulators, curcumin and sulfasalazine, enhance IDV antiretroviral activity in HIV-1 persistently infected cells |
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سنة النشر: | 2008 |
المجموعة: | Biblioteca Digital FCEN-UBA (Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires) |
مصطلحات موضوعية: | anti human immunodeficiency virus agent, curcumin, enzyme inhibitor, Gag protein, indinavir, NF kappa B kinase, NF-kappa B kinase, protein serine threonine kinase, proteinase inhibitor, salazosulfapyridine, unclassified drug, article, CD4+ T lymphocyte, cell line, cell survival, drug effect, drug potentiation, human, Human immunodeficiency virus 1, metabolism, physiology, virology, Anti-HIV Agents, CD4-Positive T-Lymphocytes, Drug Synergism, Enzyme Inhibitors, HIV Core Protein p24, HIV Protease Inhibitors, HIV-1, Humans |
الوصف: | Since the appearance of resistance to antiretroviral treatment is unavoidable, the host cell's transcription factor NF-kappaB is a novel HIV target. The goal of this study was to characterize the effect of two immunomodulators, curcumin (Cur) and sulfasalazine (Sul), with a protease inhibitor, indinavir (IDV), on HIV-1 persistently infected CD4+ T-cells. Viral p24 antigen production, viral infectivity (tested on MAGI cells) and viral relative infectivity (viral infectivity/p24) were analysed. When used alone, both immunomodulators were able to reduce viral infectivity. When in combination, both 10 μM IDV plus 10 μM Cur and 10 μM IDV plus 250 μM Sul showed a significant reduction in viral infectivity and viral relative infectivity when compared to the reduction produced by IDV alone. Thus, the use of immunomodulators with IDV could help to reduce HIV-1 production in persistently infected cells. © 2008 Springer-Verlag. |
نوع الوثيقة: | other/unknown material |
اللغة: | unknown |
Relation: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03048608_v153_n3_p561_Riva; http://hdl.handle.net/20.500.12110/paper_03048608_v153_n3_p561_Riva |
الاتاحة: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03048608_v153_n3_p561_Riva https://hdl.handle.net/20.500.12110/paper_03048608_v153_n3_p561_Riva |
رقم الانضمام: | edsbas.1A8C3EA2 |
قاعدة البيانات: | BASE |
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