Academic Journal
Comparison of point-shear wave elastography (ElastPQ) and transient elastography (FibroScan) for liver fibrosis staging in patients with non-alcoholic fatty liver disease
| العنوان: | Comparison of point-shear wave elastography (ElastPQ) and transient elastography (FibroScan) for liver fibrosis staging in patients with non-alcoholic fatty liver disease |
|---|---|
| المؤلفون: | Roccarina, D, Iogna Prat, L, Pallini, G, Guerrero Misas, M, Buzzetti, E, Saffioti, F, Aricò, FM, Mantovani, A, Koutli, E, Goyale, A, Rosselli, M, Luong, TV, Pinzani, M, Tsochatzis, EA |
| المصدر: | Liver International , 42 (10) pp. 2195-2203. (2022) |
| بيانات النشر: | WILEY |
| سنة النشر: | 2022 |
| المجموعة: | University College London: UCL Discovery |
| مصطلحات موضوعية: | acoustic radiation force impulse, Elast-PQ point-shear wave elastography, liver elastography, liver fibrosis, non-alcoholic fatty liver disease, transient elastography |
| الوصف: | Background and Aims: ElastPQ is a point shear wave elastography technique used to non-invasively assess liver fibrosis. We compared liver stiffness measurements (LSM) by ElastPQ and fibroscan transient elastography (F-TE) in a cohort of patients with non-alcoholic fatty liver disease (NAFLD). We further evaluated the performance of ElastPQ in a subgroup of patients with available liver histology. / Materials and Methods: We included patients with NAFLD who presented in a dedicated multidisciplinary clinic. Anthropometric parameters, blood tests and elastography measurements were obtained using F-TE and ElastPQ as part of routine clinical care. / Results: We enrolled 671 patients with NAFLD, mean age 55.8 ± 13 years, body mass index (BMI) 31.5 ± 5.7 kg/m2, 56.6% males, 41% diabetes, 53.7% hypertension, 68% dyslipidaemia. ElastPQ showed an excellent correlation with F-TE (Spearman's r = 0.80, p <.001), which was better for mild/moderate stages of fibrosis. Independent predictors of a >2 kPa discrepancy between the two techniques were a larger waist circumference and F-TE ≥10 kPa. In the subgroup of 159 patients with available histology, ElastPQ showed similar diagnostic accuracy with F-TE in staging liver fibrosis (ElastPQ area under the curves 0.84, 0.83, 0.86 and 0.95, for F ≥ 1, F ≥ 2, F ≥ 3 and F = 4 respectively). Optimal cut-off values of ElastPQ for individual fibrosis stages were lower than those of F-TE. / Conclusions: ElastPQ shows an excellent correlation with F-TE in patients with NAFLD, which was better for lower LSM. The optimal cut-off values of ElastPQ are lower than those of F-TE for individual stages of fibrosis. ElastPQ has similar diagnostic accuracy to F-TE for all stages of fibrosis. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| Relation: | https://discovery.ucl.ac.uk/id/eprint/10152857/1/Tsochatzis_Manuscript%20revised%20without%20editing%20marks.pdf; https://discovery.ucl.ac.uk/id/eprint/10152857/ |
| الاتاحة: | https://discovery.ucl.ac.uk/id/eprint/10152857/1/Tsochatzis_Manuscript%20revised%20without%20editing%20marks.pdf https://discovery.ucl.ac.uk/id/eprint/10152857/ |
| Rights: | open |
| رقم الانضمام: | edsbas.1A6813AB |
| قاعدة البيانات: | BASE |
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