Academic Journal
Efficacy of a cold‐adapted, intranasal, equine influenza vaccine: challenge trials
| العنوان: | Efficacy of a cold‐adapted, intranasal, equine influenza vaccine: challenge trials |
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| المؤلفون: | TOWNSEND, H. G. G., PENNER, S. J., WATTS, T. C., COOK, A., BOGDAN, J., HAINES, D. M., GRIFFIN, S., CHAMBERS, T., HOLLAND, R. E., WHITAKER‐DOWLING, P., YOUNGNER, J. S., SEBRING, R. W. |
| المصدر: | Equine Veterinary Journal ; volume 33, issue 7, page 637-643 ; ISSN 0425-1644 2042-3306 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2001 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Summary A randomised, controlled, double‐blind, influenza virus, aerosol challenge of horses was undertaken to determine the efficacy of a cold‐adapted, temperature sensitive, modified‐live virus, intranasal, equine influenza vaccine. Ninety 11‐month‐old influenza‐naïve foals were assigned randomly to 3 groups (20 vaccinates and 10 controls per group) and challenged 5 weeks, 6 and 12 months after a single vaccination. Challenges were performed on Day 0 in a plastic‐lined chamber. Between Days 1 and 10, animals were examined daily for evidence of clinical signs of influenza. Nasal swabs for virus isolation were obtained on Day 1 and Days 1 to 8 and blood samples for serology were collected on Days 1, 7 and 14. There was no adverse response to vaccination in any animal. Following challenge at 5 weeks and 6 months, vaccinates had significantly lower clinical scores (P = 0.0001 and 0.005, respectively), experienced smaller increases in rectal temperature (P = 0.0008 and 0.0007, respectively) and shed less virus (P<0.0001 and P = 0.03, respectively) over fewer days (P<0.0001 and P = 0.002, respectively) than did the controls. After the 12 month challenge, rectal temperatures (P = 0.006) as well as the duration (P = 0.03) and concentration of virus shed (P = 0.04) were significantly reduced among vaccinated animals. The results of this study showed that 6 months after a single dose of vaccine the duration and severity of clinical signs were markedly reduced amongst vaccinated animals exposed to a severe live‐virus challenge. Appropriate use of this vaccine should lead to a marked reduction in the frequency, severity and duration of outbreaks of equine influenza in North America. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.2746/042516401776249354 |
| الاتاحة: | http://dx.doi.org/10.2746/042516401776249354 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.2746%2F042516401776249354 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.19A25792 |
| قاعدة البيانات: | BASE |
| DOI: | 10.2746/042516401776249354 |
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