Academic Journal
Pituitary dysfunction following mild traumatic brain injury in female athletes
| العنوان: | Pituitary dysfunction following mild traumatic brain injury in female athletes |
|---|---|
| المؤلفون: | Claessen, Lára Ósk Eggertsdóttir, Kristjánsdóttir, Hafrún, Jónsdóttir, María Kristín, Lund, Sigrún Helga, Kristensen, Ingunn Unnsteinsdóttir, Sigurjónsdóttir, Helga Ágústa |
| المساهمون: | Faculty of Medicine, Department of Sport Science, Department of Psychology, Faculty of Physical Sciences, Other departments, Landspitali - The National University Hospital of Iceland |
| سنة النشر: | 2024 |
| المجموعة: | Opin vísindi (Iceland) |
| مصطلحات موضوعية: | Svæfinga- og gjörgæslulæknisfræði, Sálfræði, Innkirtlalæknisfræði, female athletes, hyperprolactinemia, hypopituitarism (HP), mild traumatic brain injury (mTBI), sport-related concussion (SRC), traumatic brain injury (TBI), Internal Medicine, Endocrinology, Diabetes and Metabolism |
| الوصف: | Publisher Copyright: © 2024 the author(s). ; Objective: Pituitary dysfunction following mild traumatic brain injury can have serious physical and psychological consequences, making correct diagnosis and treatment essential. To the best of our knowledge, this study is the first to study the prevalence of pituitary dysfunction following mild traumatic brain injury in an all-female population following detailed endocrinological work-up after screening for pituitary dysfunction in female athletes. Design: This is a retrospective cohort study. Methods: Hormone screening blood tests, including serum blood values for thyroid-stimulating hormone, free thyroxin, insulin-like growth factor 1, prolactin, cortisol, follicle-stimulating hormone, luteinizing hormone, estrogen and progesterone, were taken in 133 female athletes. Results were repeatedly outside the reference value in 88 women necessitating further endocrinological evaluation. Two of those were lost to follow-up, and further endocrinological evaluation was performed in 86 participants. Results: Six women (4.6%, n = 131) were diagnosed with hypopituitarism, four (3.1%) with central hypothyroidism and two with growth hormone deficiency (1.5%). Ten women (7.6%) had hyperprolactinemia, and four (3.1%) of them had prolactinoma. Medical treatment was initiated in 13 (9.9%) women. Significant prognostic factors were not found. Conclusions: As 12.2% of female athletes with a history of mild traumatic brain injury had pituitary dysfunction (hypopituitarism 4.6%, hyperprolactinemia 7.6%), we conclude that pituitary dysfunction is an important consideration in post-concussion care. Hyperprolactinemia in the absence of prolactinoma may represent pituitary or hypothalamic injury following mild traumatic brain injury. Significance statement Mild traumatic brain injury (mTBI) has become a growing public health concern as 50 million people worldwide sustain a traumatic brain injury annually, with mTBI being the most common (70–90%). As studies on mTBI have focused on mostly ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2049-3614 |
| Relation: | Endocrine Connections; 13(2); http://www.scopus.com/inward/record.url?scp=85182817180&partnerID=8YFLogxK; Claessen , L Ó E , Kristjánsdóttir , H , Jónsdóttir , M K , Lund , S H , Kristensen , I U & Sigurjónsdóttir , H Á 2024 , ' Pituitary dysfunction following mild traumatic brain injury in female athletes ' , Endocrine Connections , vol. 13 , no. 2 , e230363 . https://doi.org/10.1530/EC-23-0363; 216563243; 3fe207eb-ba6d-4695-b030-3a1608722037; 85182817180; https://hdl.handle.net/20.500.11815/4701 |
| DOI: | 10.1530/EC-23-0363 |
| الاتاحة: | https://hdl.handle.net/20.500.11815/4701 https://doi.org/10.1530/EC-23-0363 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.189D7BC |
| قاعدة البيانات: | BASE |
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