Academic Journal
Optimal staging system for predicting the prognosis of patients with hepatocellular carcinoma in China: a retrospective study
| العنوان: | Optimal staging system for predicting the prognosis of patients with hepatocellular carcinoma in China: a retrospective study |
|---|---|
| المؤلفون: | Su, Lihui, Zhou, Tao, Zhang, Zongli, Zhang, Xiuguo, Zhi, Xuting, Li, Caixia, Wang, Qingliang, Jia, Chongqi, Shi, Wenna, Yue, Yanqiu, Gao, Yanjing, Cheng, Baoquan |
| بيانات النشر: | BioMed Central Ltd. |
| سنة النشر: | 2016 |
| المجموعة: | BioMed Central |
| مصطلحات موضوعية: | Hepatocellular carcinoma, Prognosis, Staging system, Independent predictors, Overall survival |
| الوصف: | Background Several staging systems have been developed to evaluate patients with hepatocellular carcinoma (HCC), including the China Staging System (CS), the American Joint Committee on Cancer (AJCC) tumor-node-metastasis (TNM) staging system, and seventh edition; the Barcelona Clinic Liver Cancer (BCLC) staging system, and Cancer of the Liver Italian Program (CLIP) staging system. The optimal staging system for to evaluate patients in China with HCC has not been determined. This study was designed to determine the optimal staging system for predicting patient prognosis by comparing the performances of these four staging systems in a cohort of Chinese patients with HCC. Methods This study enrolled 307 consecutive Chinese patients with HCC in Shandong Province. The performances of the CS, TNM, BCLC, and CLIP staging systems were compared and ranked using a concordance index. Predictors of survival were identified using univariate and multivariate Cox model analyses. Results The mean overall survival of the patient cohort was 12.08 ± 11.87 months. Independent predictors of survival included tumor size, number of lesions, tumor thromboses, cirrhosis, serum albumin level and serum total bilirubin level. Compared with the other three staging systems, the CS staging system showed optimal performance as an independent predictor of patient survival. The BCLC staging system showed the poorest performance; its treatment algorithm was not suitable for patients in this study. Conclusions CS was the most suitable staging system for predicting survival of patients with HCC in China. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | http://www.biomedcentral.com/1471-2407/16/424 |
| الاتاحة: | http://www.biomedcentral.com/1471-2407/16/424 |
| Rights: | Copyright 2016 The Author(s). |
| رقم الانضمام: | edsbas.187803EF |
| قاعدة البيانات: | BASE |
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