Academic Journal
Impact of skin capsular distance on the performance of controlled attenuation parameter in patients with chronic liver disease
| العنوان: | Impact of skin capsular distance on the performance of controlled attenuation parameter in patients with chronic liver disease |
|---|---|
| المؤلفون: | Shen, Feng, Zheng, Rui‐Dan, Shi, Jun‐Ping, Mi, Yu‐Qiang, Chen, Guo‐Feng, Hu, Xiqi, Liu, Yong‐Gang, Wang, Xiao‐Ying, Pan, Qin, Chen, Guang‐Yu, Chen, Jian‐Neng, Xu, Liang, Zhang, Rui‐Nan, Xu, Lei‐Ming, Fan, Jian‐Gao |
| المساهمون: | The National Key Basic Research Project, Chinese Foundation for Hepatitis Prevention and Control - ‘WANG Bao-En’ Liver Fibrosis Research Fund, ‘Tian-qing-gan-bing’ Research Fund |
| المصدر: | Liver International ; volume 35, issue 11, page 2392-2400 ; ISSN 1478-3223 1478-3231 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2015 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Background & Aims Controlled attenuation parameter ( CAP ) is a non‐invasive method for evaluating hepatic steatosis. However, larger skin capsular distance ( SCD ) can affect the accuracy. The aim of this study was to investigate the impact of SCD on the diagnostic performance of CAP and liver stiffness measurement ( LSM ). Methods Of 101 patients with non‐alcoholic fatty liver disease ( NAFLD ) and 280 patients with chronic hepatitis B ( CHB ) who underwent liver biopsy were prospectively recruited. CAP , LSM and SCD were performed using FibroScan with M probe. The areas under receiver operating characteristics curves ( AUROC s) were calculated to determine the diagnostic efficacy. The optimal thresholds were defined by the maximum Youden index. Results SCD (B 30.34, P < 0.001) and hepatic steatosis (B 23.04, P < 0.001) were independently associated with CAP by multivariate analysis. The AUROC s were slightly higher for SCD <25 mm compared to those for SCD ≥25 mm for steatosis ≥5% (0.88 vs. 0.81), >33% (0.90 vs. 0.85) and >66% (0.84 vs. 0.72). For SCD <25 mm, the optimal CAP cut‐offs for differentiating steatosis ≥5%, >33% and >66% were 255.0 dB /m, 283.5 dB /m and 293.5 dB /m. However, cut‐offs were elevated by approximately 60–70 dB /m for SCD ≥25 mm. When stratified by fibrosis grade, LSM was significantly affected by SCD ≥25 mm for advanced fibrosis (≥F3) in NAFLD , but not in CHB. Conclusion CAP is a promising tool for detecting and quantifying hepatic steatosis. SCD ≥25 mm may cause overestimation of steatosis. Similarly, SCD ≥25 mm affects the detection of advanced fibrosis by LSM in NAFLD patients. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/liv.12809 |
| الاتاحة: | http://dx.doi.org/10.1111/liv.12809 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fliv.12809 https://onlinelibrary.wiley.com/doi/pdf/10.1111/liv.12809 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/liv.12809 |
| Rights: | http://creativecommons.org/licenses/by-nc/4.0/ |
| رقم الانضمام: | edsbas.1723BDD6 |
| قاعدة البيانات: | BASE |
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