Academic Journal
Platelets as inflammatory mediators in a murine model of periodontitis
| العنوان: | Platelets as inflammatory mediators in a murine model of periodontitis |
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| المؤلفون: | Zhan, Yalin, Lu, Ruifang, Meng, Huanxin, Hou, Jianxia, Huang, Wenxue, Wang, Xian'e, Hu, Wenjie |
| المصدر: | Journal of Clinical Periodontology ; volume 47, issue 5, page 572-582 ; ISSN 0303-6979 1600-051X |
| بيانات النشر: | Wiley |
| سنة النشر: | 2020 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Aim To investigate the role of platelets during the development of ligature‐induced experimental periodontitis in mice. Materials and Methods Experimental periodontitis was induced by placement of sterilized 5‐0 cotton ligatures around the maxillary and mandibular second molars of C57BL/6 wild‐type mice. Flow cytometry was used to analyse platelet activation and platelet–leucocyte aggregate formation, and histologic analysis was used to evaluate inflammation and localization of platelets and leucocytes in periodontal tissues during the development of experimental periodontitis and in experimental periodontitis with and without antiplatelet drug treatment. Results Experimental periodontitis induced platelet activation and platelet–leucocyte interaction. Platelets and leucocytes gradually infiltrated in inflammatory gingival tissues during the development of experimental periodontitis. The inhibition of platelet activation via drug therapy led to significant inhibition of leucocyte migration and marked reduction in periodontal inflammation. Conclusion This study revealed that platelets are critical for inflammation and tissue injury in periodontitis and serve as mediators of inflammation in periodontal tissue. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/jcpe.13265 |
| الاتاحة: | http://dx.doi.org/10.1111/jcpe.13265 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fjcpe.13265 https://onlinelibrary.wiley.com/doi/pdf/10.1111/jcpe.13265 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/jcpe.13265 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.15782811 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/jcpe.13265 |
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