Conference
Presentation_1_Maintenance therapy of low-dose nivolumab, S-1, and leucovorin in metastatic pancreatic adenocarcinoma with a germline mutation of MSH6: A case report.pptx
| العنوان: | Presentation_1_Maintenance therapy of low-dose nivolumab, S-1, and leucovorin in metastatic pancreatic adenocarcinoma with a germline mutation of MSH6: A case report.pptx |
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| المؤلفون: | Shang-Hsuan Peng (14249798), Bang-Bin Chen (739057), Ting-Chun Kuo (3090399), Jen-Chieh Lee (437384), Shih-Hung Yang (4225765) |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Immunology, Applied Immunology (incl. Antibody Engineering, Xenotransplantation and T-cell Therapies), Autoimmunity, Cellular Immunology, Humoural Immunology and Immunochemistry, Immunogenetics (incl. Genetic Immunology), Innate Immunity, Transplantation Immunology, Tumour Immunology, Immunology not elsewhere classified, Genetic Immunology, Animal Immunology, Veterinary Immunology, pancreatic ductal adenocarcinoma, nivolumab, maintenance therapy, mismatch repair, case report |
| الوصف: | Immune checkpoint inhibitors (ICIs) provide substantial benefits to a small subset of patients with advanced cancer with mismatch repair deficiency (MMRD) or microsatellite instability (MSI), including patients with pancreatic ductal adenocarcinoma (PDAC). However, the long duration of ICI treatment presents a considerable financial burden. We present the case of a 63-year-old woman with metastatic PDAC refractory to conventional chemotherapy. Genetic analyses identified an MSH6 germline mutation and a high tumor mutation burden (TMB). Complete response (CR) was achieved after a short course of low-dose nivolumab (20 mg once every 2 weeks) with chemotherapy. CR was maintained for over 1 year with low-dose nivolumab and de-escalated chemotherapy without any immune-related adverse events. This case supports the further exploration of low-dose, affordable ICI-containing regimens in patients with advanced MSI-high/TMB-high cancer. |
| نوع الوثيقة: | conference object |
| اللغة: | unknown |
| Relation: | https://figshare.com/articles/presentation/Presentation_1_Maintenance_therapy_of_low-dose_nivolumab_S-1_and_leucovorin_in_metastatic_pancreatic_adenocarcinoma_with_a_germline_mutation_of_MSH6_A_case_report_pptx/21715559 |
| DOI: | 10.3389/fimmu.2022.1077840.s001 |
| الاتاحة: | https://doi.org/10.3389/fimmu.2022.1077840.s001 |
| Rights: | CC BY 4.0 |
| رقم الانضمام: | edsbas.12A84E81 |
| قاعدة البيانات: | BASE |
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