Academic Journal
TRPM2 ion channels steer neutrophils towards a source of hydrogen peroxide
| العنوان: | TRPM2 ion channels steer neutrophils towards a source of hydrogen peroxide |
|---|---|
| المؤلفون: | Morad, Hassan, Luqman, Suaib, Tan, Chun-Hsiang, Swann, Victoria, McNaughton, Peter A. |
| المساهمون: | Wellcome Trust |
| المصدر: | Scientific Reports ; volume 11, issue 1 ; ISSN 2045-2322 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2021 |
| الوصف: | Neutrophils must navigate accurately towards pathogens in order to destroy invaders and thus defend our bodies against infection. Here we show that hydrogen peroxide, a potent neutrophil chemoattractant, guides chemotaxis by activating calcium-permeable TRPM2 ion channels and generating an intracellular leading-edge calcium “pulse”. The thermal sensitivity of TRPM2 activation means that chemotaxis towards hydrogen peroxide is strongly promoted by small temperature elevations, suggesting that an important function of fever may be to enhance neutrophil chemotaxis by facilitating calcium influx through TRPM2. Chemotaxis towards conventional chemoattractants such as LPS, CXCL2 and C5a does not depend on TRPM2 but is driven in a similar way by leading-edge calcium pulses. Other proposed initiators of neutrophil movement, such as PI3K, Rac and lyn , influence chemotaxis by modulating the amplitude of calcium pulses. We propose that intracellular leading-edge calcium pulses are universal drivers of the motile machinery involved in neutrophil chemotaxis. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41598-021-88224-5 |
| الاتاحة: | http://dx.doi.org/10.1038/s41598-021-88224-5 https://www.nature.com/articles/s41598-021-88224-5.pdf https://www.nature.com/articles/s41598-021-88224-5 |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.1073FBCE |
| قاعدة البيانات: | BASE |
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