Fatal herpesvirus-6 encephalitis in a recipient of a T-cell-depleted peripheral blood stem cell transplant from a 3-loci mismatched related donor
| العنوان: | Fatal herpesvirus-6 encephalitis in a recipient of a T-cell-depleted peripheral blood stem cell transplant from a 3-loci mismatched related donor |
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| المؤلفون: | Tiacci, E., Mario LUPPI, Barozzi, P., Gurdo, G., Tabilio, A., Ballanti, S., Torelli, G., Aversa, F. |
| المصدر: | Scopus-Elsevier Europe PubMed Central |
| مصطلحات موضوعية: | Male, Transplantation Conditioning, Herpesvirus 6, Human, Hematopoietic Stem Cell Transplantation, Graft vs Host Disease, Herpesviridae Infections, Middle Aged, Polymerase Chain Reaction, Lymphocyte Depletion, Tissue Donors, T-cell-depleted mismatched transplant, Fatal Outcome, HHV-6 encephalitis, Histocompatibility, Cytomegalovirus Infections, DNA, Viral, Humans, Virus Activation, Encephalitis, Viral, Ganciclovir, Immunosuppressive Agents, Foscarnet |
| الوصف: | Human herpesvirus-6 (HHV-6), like all the other herpes viruses, remains latent in host cells after primary infection but can be reactivated in immunocompromised patients causing fever, skin rash, bone marrow (BM) suppression, pneumonitis, sinusitis and meningoencephalitis. We describe the case of a man with chronic myelogenous leukemia who developed encephalitis associated with acute graft-versus-host disease two months after a T-cell-depleted mismatched peripheral blood stem cell transplant. Magnetic resonance images of the brain revealed multiple bilateral foci of signal abnormality. HHV-6 was the only pathogen detected in cerebrospinal fluid by PCR. Treatment with both ganciclovir and foscarnet was unsuccessful and the patient gradually deteriorated and died. Other cases of HHV-6 encephalitis after bone marrow transplantation are reviewed. |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::078c32b8d758e05e04b13d94c402bbf8 http://www.scopus.com/inward/record.url?eid=2-s2.0-0033951514&partnerID=MN8TOARS |
| Rights: | OPEN |
| رقم الانضمام: | edsair.pmid.dedup....078c32b8d758e05e04b13d94c402bbf8 |
| قاعدة البيانات: | OpenAIRE |
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