[Analysis of gag-specific IFN-gamma secretion responses in HIV-1 B/C recombinant infectors]
| العنوان: | [Analysis of gag-specific IFN-gamma secretion responses in HIV-1 B/C recombinant infectors] |
|---|---|
| المؤلفون: | Hong-Wei, Liu, Kun-Xue, Hong, Yuan, Yuan, Chun-Hua, Liu, Jian-Ping, Chen, Yu-Hua, Ruan, Zhe, Wang, Yi-Ming, Shao |
| المصدر: | Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology. 25(5) |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | CD4-Positive T-Lymphocytes, Recombination, Genetic, Interferon-gamma, Immunodominant Epitopes, HIV-1, Gene Products, gag, Humans, HIV Infections |
| الوصف: | To characterize the Gag-Specific T lymphocyte responses and identify immunodominant region recognized in Chinese HIV-1 recombinant subtype B/C infectors.10 antiretroviral treatment (ART) naive HIV-1 recombinant subtype B/C infectors with infected time in 1 year, 25 ART-naive infectors with infected time3 years and 10 HIV-1-seronegative healthy individuals were enrolled. HIV-1-specific T lymphocyte responses were analyzed by an IFN-gamma Elispot assay against 123 overlapping peptides spanning HIV-1 Gag protein in the present study.Gag-specific T lymphocyte responses of interferon-gamma secretion were identified in 8(8/10) Chinese HIV-1 recombinant subtype B/ C infectors with infected time in 1 year, the specific T lymphocytes are mainly targeted at five seperated peptides. Responses were identified in 17(68%) infectors with infected time more than 3 years, the specific T lymphocytes are mainly targeted at one peptide in p17 and six in p24. There was obviously positive correlation (P = 0.0318, r = 0.519) between the magnitude of responses and viremia in infectors infected time3 years. The magnitude of response in infectors infected in 1 year was significantly higher than group infected time3 years (P = 0.021). None of healthy individuals produced positive responses.HIV-1 recombinant subtype B/C Infectors at different stages of diseases recognize different region of gag. |
| تدمد: | 1003-9279 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=pmid________::bfa9ad7b5e4e8e783fab3c0d8310ce20 https://pubmed.ncbi.nlm.nih.gov/22338224 |
| رقم الانضمام: | edsair.pmid..........bfa9ad7b5e4e8e783fab3c0d8310ce20 |
| قاعدة البيانات: | OpenAIRE |
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