[Establishment of Mouse Model of H-2 Haploidentical Hematopoietic Stem Cell Transplantation from Double Donors]
| العنوان: | [Establishment of Mouse Model of H-2 Haploidentical Hematopoietic Stem Cell Transplantation from Double Donors] |
|---|---|
| المؤلفون: | Xiao-Na, Wang, Yu-Meng, Liang, Lei, Deng, Lu, Wang, Yi, Wang, Ya-Jing, Huang, Tie-Qiang, Liu, Hong-Li, Zuo, Kai-Xun, Hu, Jian-Hui, Qiao, Qi-Yun, Sun, Mei, Guo, Hui-Sheng, Ai, Chang-Lin, Yu |
| المصدر: | Zhongguo shi yan xue ye xue za zhi. 25(2) |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, Disease Models, Animal, Mice, Mice, Inbred C3H, Transplantation Conditioning, Hematopoietic Stem Cell Transplantation, Animals, Graft vs Host Disease, Female, Tissue Donors, Whole-Body Irradiation |
| الوصف: | To establish a new mouse model of H-2 haploidentical stem cell transplantation from double donors (DHSCT) and compare with conventional haploidentical hematopoietic stem cell transplantation (HSCT) so as to alleviate transplant-related complications.The recipients CB6F1 of conventional HSCT group were pretreated by 8 Gy total body irradiation(TBI), and received 3×10The nadir of white blood cell count after conventional HSCT were lower than 1×10A new mouse model of H-2 haploidentical peripheral blood stem cell transplantation from double donors (DHSCT) has been successfully established by reducing conditioning intensity and increasing graft cell numbers from double haploidentical donors without GVHD prophylaxis. DHSCT successfully achieved stable complete chimerism, less GVHD morbidity and mortality and longer OS without hematopoietic suppression. This study provides experimental evidence for clinical application of HLA haploidentical peripheral blood stem cell transplantation from double donors. |
| تدمد: | 1009-2137 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=pmid________::8199301f572e07e292679f4a1369940a https://pubmed.ncbi.nlm.nih.gov/28446305 |
| رقم الانضمام: | edsair.pmid..........8199301f572e07e292679f4a1369940a |
| قاعدة البيانات: | OpenAIRE |
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