Prognostic value of generation of growth hormone-stimulated insulin-like growth factor-I (IGF-I) and its binding protein-3 in patients with compensated and decompensated liver cirrhosis
| العنوان: | Prognostic value of generation of growth hormone-stimulated insulin-like growth factor-I (IGF-I) and its binding protein-3 in patients with compensated and decompensated liver cirrhosis |
|---|---|
| المؤلفون: | N, Assy, Z, Hochberg, R, Enat, Y, Baruch |
| المصدر: | Digestive diseases and sciences. 43(6) |
| سنة النشر: | 1998 |
| مصطلحات موضوعية: | Adult, Liver Cirrhosis, Male, Pilot Projects, Middle Aged, Prognosis, Survival Analysis, Insulin-Like Growth Factor Binding Protein 3, Liver, Predictive Value of Tests, Growth Hormone, Humans, Female, Prospective Studies, Insulin-Like Growth Factor I, Biomarkers |
| الوصف: | Our aim was to study the prognostic value of growth hormone (GH) -stimulated insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 (IGFBP-3) generation in patients with compensated [group 1 (N = 8) with a Child-Pugh (CP) score of 5-8] and decompensated postnecrotic liver cirrhosis [group 2 (N = 7) with a CP score of 9-12]. Serum levels of IGF-I, GH-binding protein (GHBP), and IGFBP-3 were measured before and 24 hr after a single subcutaneous injection of recombinant human GH (rhGH, 0.14 units/kg). Patients (mean age 56 years) were followed prospectively for three years. Six patients (40%) died during the follow-up period, of whom half had a CP score9. Mean serum IGF-I levels 24 hr after rhGH injection (group 1 vs group 2, 17.4 +/- 6.8 vs 7.4 +/- 0.7 nmol/liter) predicted survival with 93% accuracy. Levels10 nmol/liter portended a poor prognosis, with 15% survival at one year, whereas levels10 nmol/liter had a 100% survival rate at one and two years, respectively. Baseline IGF-I (9.98 +/- 2.0 vs 6.38 +/- 0.8 nmol/liter), GHBP (9.2 +/- 3 vs 5.7 +/- 0.8%/50 microl), and IGFBP-3 serum levels at baseline (1.7 +/- 0.3 vs 0.86 +/- 0.2 mg/liter) and at 24 hr (2.04 +/- 0.38 vs 0.99 +/- 0.3 mg/liter) did not add to the predictive value of stimulated IGF-I levels at 24 hr and were less accurate in predicting the outcome in comparison to CP score (80%). We conclude that stimulated IGF-110 nmol/liter may be a true predictor of a negative prognosis in patients with liver cirrhosis. |
| تدمد: | 0163-2116 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=pmid________::6ba6a3a1123fc79e1b9a81cc88910ab1 https://pubmed.ncbi.nlm.nih.gov/9635625 |
| رقم الانضمام: | edsair.pmid..........6ba6a3a1123fc79e1b9a81cc88910ab1 |
| قاعدة البيانات: | OpenAIRE |
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