Minimal contribution of severe hypertriglyceridemia in L-asparaginase-associated pancreatitis developed in a child with acute lymphocytic leukemia
| العنوان: | Minimal contribution of severe hypertriglyceridemia in L-asparaginase-associated pancreatitis developed in a child with acute lymphocytic leukemia |
|---|---|
| المؤلفون: | Yoshinori, Goto, Ryosei, Nishimura, Atsushi, Nohara, Shintaro, Mase, Toshihiro, Fujiki, Hitoshi, Irabu, Rie, Kuroda, Raita, Araki, Yasuhiro, Ikawa, Hideaki, Maeba, Akihiro, Yachie |
| المصدر: | [Rinsho ketsueki] The Japanese journal of clinical hematology. 57(8) |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Hypertriglyceridemia, Pancreatitis, Asparaginase, Humans, Female, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Child, Lipid Metabolism |
| الوصف: | A 10-year-old girl developed L-asparaginase (ASP)-associated pancreatitis during chemotherapy for acute lymphocytic leukemia. Her symptoms showed alleviation with continuous regional arterial infusion of protease inhibitor and systemic somatostatin analog therapy. She had intermittent and marked hypertriglyceridemia, an initial trigger for pancreatitis, probably as a side effect of ASP and steroids. However, we considered the pancreatitis to have developed mainly because of factors other than hypertriglyceridemia as lipoprotein analysis confirmed chylomicron levels to be nearly undetectable. Extremely large chylomicrons contribute directly to the onset of pancreatitis by causing blockage of small vessels. Although it is necessary to examine patients for dyslipidemia developing as a side effect of ASP, therapeutic intervention for hypertriglyceridemia is not considered to prevent the onset of ASP-associated pancreatitis. |
| تدمد: | 0485-1439 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=pmid________::28f1016dad801ef16b2e30c8d24e4a5d https://pubmed.ncbi.nlm.nih.gov/27599414 |
| رقم الانضمام: | edsair.pmid..........28f1016dad801ef16b2e30c8d24e4a5d |
| قاعدة البيانات: | OpenAIRE |
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