Diversidad genética en poblaciones humanas de dos regiones colombianas
| العنوان: | Diversidad genética en poblaciones humanas de dos regiones colombianas |
|---|---|
| المؤلفون: | Rondón, Fernando, Osorio, Julio César, Peña, Ángela Viviana, Garcés, Héctor Andrés, Barreto, Guillermo |
| المصدر: | Colombia Médica, Volume: 39 Supplement 2, Pages: 52-60, Published: JUN 2008 |
| بيانات النشر: | Universidad del Valle, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Mixed population, Miscegenación, Colombia southwest, STR's, mtDNA, Poblaciones amerindias, Flujo génico, Genetics diversity, Sur-occidente colombiano, Amerindian populations, Genetics flow, Diversidad genética |
| الوصف: | Introducción: Estudios preliminares han mostrado la existencia de relaciones genéticas entre las poblaciones humanas del sur-occidente y las de la región andina colombiana, teniendo esto implicaciones en el grado de miscegenación de estas comunidades. No obstante el reconocimiento de este amplio proceso de mestizaje, no se tiene suficiente información que permita establecer la estructura y el grado de diversidad genética para cada región en particular y de la población colombiana en general. Objetivo: Determinar la estructura y diversidad genética presente en grupos poblacionales del centro y sur-occidente colombiano. Metodología: Se analizaron las frecuencias alélicas de 12 sistemas de microsatélites autosómicos y el tipo y frecuencia de RFLP's de mtDNA presentes en 472 individuos de tres grupos étnicos: mestizos, indígenas y afroamericanos. Resultados: La caracterización de haplotipos de mtDNA en individuos afrodescendientes presentó 15% de marcadores típicos amerindios y 43% de africanos. El análisis de la diversidad genética mostró un índice de 0.72 en individuos Pijaos, valor cercano al índice de diversidad de la población mestiza de Cali (0.75). El análisis molecular de varianza (AMOVA) a partir de los 12 STR's, mostró que la estructuración genética no es significativa (FST de 0.032); adicionalmente se evidenció alta endogamia en la muestra mestiza de Caldas (0.43) y en la muestra indígena Coyaima (0.34). Conclusiones: Con los marcadores moleculares estudiados se estableció la estructura genética de poblaciones del sur-occidente colombiano confirmándose adicionalmente el grado de miscegenación y el flujo genético ocurrido entre diferentes grupos étnicos del centro y sur-occidente colombiano. Introduction: Preliminary studies have showed close relations among southwest human populations and Andean region leaving it consequences in ethnic admixe process. However, this wide process of racial admixture today it is not exist sufficient information to define structure and genetic diversity for each region and Colombian population in general. Objectives: The principal goal from this study was to determinate the genetic structure and diversity present into human populations from Andean and Southwest Colombia regions. Methods: This study was realized by characterization allelic frequencies of 12 autosomal STR's and six RFLP's of mtDNA presents in 472 individuals from three ethnics groups: Caucasoids, Afroamericans and Amerindians. Results: mtDNA haplotypes presents in Afrodescends sample was 15% and 43% typical Amerindian and African markers respectively; the genetics diversity analysis shows a value of 0.72 in Pijao indigenous, these values are close to diversity index of mestizos from Cali (0.75). AMOVA of allelic frequencies from 12 STR's shows that genetic structures don't was significatively different (FST de 0.032); in addition it's to exhibit high endogamy in mestizos from Caldas sample (0.43) and Coyaima indigenous (0.34). Conclusions: was established genetic structure for southwest Colombian population. Additionally, the results confirm the mixing process and the genetics flow among many populations groups from Andean and southwest Colombia regions. |
| وصف الملف: | text/html |
| اللغة: | Spanish; Castilian |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=od_______618::3f38cbe84696e1ce1ef6fde49287a847 http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S1657-95342008000600008&lng=en&tlng=en |
| Rights: | OPEN |
| رقم الانضمام: | edsair.od.......618..3f38cbe84696e1ce1ef6fde49287a847 |
| قاعدة البيانات: | OpenAIRE |
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No obstante el reconocimiento de este amplio proceso de mestizaje, no se tiene suficiente información que permita establecer la estructura y el grado de diversidad genética para cada región en particular y de la población colombiana en general. Objetivo: Determinar la estructura y diversidad genética presente en grupos poblacionales del centro y sur-occidente colombiano. Metodología: Se analizaron las frecuencias alélicas de 12 sistemas de microsatélites autosómicos y el tipo y frecuencia de RFLP's de mtDNA presentes en 472 individuos de tres grupos étnicos: mestizos, indígenas y afroamericanos. Resultados: La caracterización de haplotipos de mtDNA en individuos afrodescendientes presentó 15% de marcadores típicos amerindios y 43% de africanos. El análisis de la diversidad genética mostró un índice de 0.72 en individuos Pijaos, valor cercano al índice de diversidad de la población mestiza de Cali (0.75). El análisis molecular de varianza (AMOVA) a partir de los 12 STR's, mostró que la estructuración genética no es significativa (FST de 0.032); adicionalmente se evidenció alta endogamia en la muestra mestiza de Caldas (0.43) y en la muestra indígena Coyaima (0.34). Conclusiones: Con los marcadores moleculares estudiados se estableció la estructura genética de poblaciones del sur-occidente colombiano confirmándose adicionalmente el grado de miscegenación y el flujo genético ocurrido entre diferentes grupos étnicos del centro y sur-occidente colombiano. Introduction: Preliminary studies have showed close relations among southwest human populations and Andean region leaving it consequences in ethnic admixe process. However, this wide process of racial admixture today it is not exist sufficient information to define structure and genetic diversity for each region and Colombian population in general. Objectives: The principal goal from this study was to determinate the genetic structure and diversity present into human populations from Andean and Southwest Colombia regions. Methods: This study was realized by characterization allelic frequencies of 12 autosomal STR's and six RFLP's of mtDNA presents in 472 individuals from three ethnics groups: Caucasoids, Afroamericans and Amerindians. Results: mtDNA haplotypes presents in Afrodescends sample was 15% and 43% typical Amerindian and African markers respectively; the genetics diversity analysis shows a value of 0.72 in Pijao indigenous, these values are close to diversity index of mestizos from Cali (0.75). AMOVA of allelic frequencies from 12 STR's shows that genetic structures don't was significatively different (FST de 0.032); in addition it's to exhibit high endogamy in mestizos from Caldas sample (0.43) and Coyaima indigenous (0.34). Conclusions: was established genetic structure for southwest Colombian population. 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