Epigenetic regulation of pancreatic adenocarcinoma in the era of cancer immunotherapy
| العنوان: | Epigenetic regulation of pancreatic adenocarcinoma in the era of cancer immunotherapy |
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| المؤلفون: | Kazumichi Kawakubo, Carlos Fernandez-del Castillo, Andrew Scott Liss |
| المصدر: | Journal of Gastroenterology. 57:819-826 |
| بيانات النشر: | Springer Science and Business Media LLC, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Pancreatic Neoplasms, Tumor Microenvironment, Gastroenterology, Humans, Immunotherapy, Adenocarcinoma, Immune Checkpoint Inhibitors, Epigenesis, Genetic |
| الوصف: | Pancreatic adenocarcinoma is a lethal cancer with poor response to chemotherapy and immune checkpoint inhibitors. Recent studies suggest that epigenetic alterations contribute to its aggressive biology and the tumor microenvironment which render it unresponsive to immune checkpoint blockade. Here, we review our current understandings of epigenetic dysregulation in pancreatic adenocarcinoma, its effect on the tumor immune microenvironment, and the potential for epigenetic therapy to be combined with immune checkpoint inhibitors. |
| تدمد: | 1435-5922 0944-1174 |
| DOI: | 10.1007/s00535-022-01915-2 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fff96ac11c8ec132ee0e5f20bbe0bb56 https://doi.org/10.1007/s00535-022-01915-2 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fff96ac11c8ec132ee0e5f20bbe0bb56 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14355922 09441174 |
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| DOI: | 10.1007/s00535-022-01915-2 |