Development of Non-C2-symmetric ProPhenol Ligands. The Asymmetric Vinylation of N-Boc Imines
| العنوان: | Development of Non-C2-symmetric ProPhenol Ligands. The Asymmetric Vinylation of N-Boc Imines |
|---|---|
| المؤلفون: | Dennis C. Koester, Yan Miller, Chao-I Joey Hung, Barry M. Trost |
| المصدر: | Organic Letters. 17:3778-3781 |
| بيانات النشر: | American Chemical Society (ACS), 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Allylic rearrangement, Stereochemistry, Chemistry, Ligand, Organic Chemistry, Rational design, Enantioselective synthesis, Physical and Theoretical Chemistry, Biochemistry, Catalysis |
| الوصف: | The development and application of a new generation of non-C2-symmetric ProPhenol ligands is reported herein. Rational design of the ProPhenol ligand paved the way to the first catalytic and asymmetric vinylation of N-Boc imines via hydrozirconation giving rise to valuable allylic amines in excellent yields and enantioselectivities. The utility of this method was demonstrated by developing the shortest reported asymmetric synthesis of the selective serotonine reuptake inhibitor (SSRI) (-)-dapoxetine. |
| تدمد: | 1523-7052 1523-7060 |
| DOI: | 10.1021/acs.orglett.5b01755 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc2c8ccb7622a2fb95c2df8afc84ca11 https://doi.org/10.1021/acs.orglett.5b01755 |
| رقم الانضمام: | edsair.doi.dedup.....fc2c8ccb7622a2fb95c2df8afc84ca11 |
| قاعدة البيانات: | OpenAIRE |
كن أول من يترك تعليقا!