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Limb body wall complex: Its delineation and relationship with amniotic bands using clustering methods

التفاصيل البيبلوغرافية
العنوان: Limb body wall complex: Its delineation and relationship with amniotic bands using clustering methods
المؤلفون: Hebe Campaña, Lucas Gabriel Gimenez, María Rita Santos, Mariela Pawluk, Viviana Cosentino, Jorge S. Lopez-Camelo, Fernando A. Poletta, Monica Rittler, Juan Antonio Gili
المصدر: Birth defects research. 111(4)
سنة النشر: 2018
مصطلحات موضوعية: 0301 basic medicine, Male, Embryology, CIENCIAS MÉDICAS Y DE LA SALUD, Databases, Factual, Ectromelia, Health, Toxicology and Mutagenesis, Amniotic Band, Ciencias de la Salud, Maternity hospitals, 030105 genetics & heredity, Toxicology, Lower limb, body wall defects, 03 medical and health sciences, Limb body wall complex, Epidemiología, Medicine, Humans, amniotic bands, Abnormalities, Multiple, Retrospective Studies, business.industry, Infant, Newborn, Anatomy, Stillbirth, 030104 developmental biology, medicine.anatomical_structure, Homogeneous, Pediatrics, Perinatology and Child Health, amelia, Upper limb, Female, Amniotic Band Syndrome, limb body wall complex, business, LBWC, cluster analysis, Developmental Biology
الوصف: BACKGROUND:Despite the numerous reports on the limb body wall complex (LBWC), this association has never been adequately defined. Amniotic bands (AB) are frequently present but their role remains unclear. Since most reports were based on clinical and often subjective diagnoses, the aim of this work was to define LBWC and the role of AB, minimizing subjectivity.METHODS:Data were obtained from the ECLAMC maternity hospitals network database. A total of 450 live and stillborn infants, born during 1967-2013, with AB or the LBWC were selected. A hierarchical cluster analysis was used to classify cases into homogeneous groups (sharing similar associated defects); robustness of the classification was confirmed with a discriminant analysis. The frequency of associated defects was compared among groups; those whose frequency differed significantly were included in a logistic regression to establish their association within each group.RESULTS:The cluster analysis identified two groups: a body wall defect (BWD) predominating in one, AB in the other. These groups were further divided into: BWD (cases with only BWD), AB (with only AB), BWD + AB, and NONE (with neither). Association with caudal defects and lower limb amelia was observed for BWD, with cephalic defects and upper limb amputations for BWD + AB.CONCLUSIONS:The results, obtained with the least possible subjectivity, indicated that BWD and BWD + AB are different conditions. Since BWD specifically associates with amelia, we propose that this defect and not any limb deficiency should be considered as inclusion criterium and that it should be included in the BWD acronym as LBWC. Fil: Rittler, Monica. Universidad de Buenos Aires; Argentina Fil: Campaña, Hebe. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina. Comisión de Investigaciones Científicas, Buenos Aires; Argentina Fil: Poletta, Fernando Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina. Instituto Nacional de Genética Médica Poblacional; Brasil Fil: Santos, María Rita. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina Fil: Gili, Juan Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina Fil: Pawluk, Mariela Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina Fil: Cosentino, Viviana Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina Fil: Gimenez, Lucas Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina Fil: López Camelo, Jorge Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina. Instituto Nacional de Genética Médica Poblacional; Brasil
وصف الملف: application/pdf
تدمد: 2472-1727
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc05313806c386a2e560d19ea2aacf9f
https://pubmed.ncbi.nlm.nih.gov/30589520
Rights: RESTRICTED
رقم الانضمام: edsair.doi.dedup.....fc05313806c386a2e560d19ea2aacf9f
قاعدة البيانات: OpenAIRE
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تدمد:24721727