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Effects of quercetin on cadmium-induced toxicity in rat urine using metabonomics techniques

التفاصيل البيبلوغرافية
العنوان: Effects of quercetin on cadmium-induced toxicity in rat urine using metabonomics techniques
المؤلفون: Y Liu, X Zhang, T Guan, S Jia, X Zhao
المصدر: Human & Experimental Toxicology. 39:524-536
بيانات النشر: SAGE Publications, 2019.
سنة النشر: 2019
مصطلحات موضوعية: Male, 0301 basic medicine, Allantoic acid, Taurine, Antioxidant, Health, Toxicology and Mutagenesis, medicine.medical_treatment, Urine, Pharmacology, Kidney, Toxicology, Antioxidants, Phosphocreatine, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine, Animals, Metabolomics, heterocyclic compounds, General Medicine, 030104 developmental biology, Liver, chemistry, 030220 oncology & carcinogenesis, Toxicity, Metabolome, Uric acid, Environmental Pollutants, Quercetin, Biomarkers, Cadmium
الوصف: This study aimed to analyse the protective effects of quercetin on the toxicity of cadmium (Cd) using metabonomics techniques. Sixty male Sprague–Dawley rats were randomly divided into six groups ( n = 10): control group (C), low-dose quercetin-treated group (Q1; 10 mg/kg bw/day), high-dose quercetin-treated group (Q2; 50 mg/kg bw/day), Cd-treated group (D; 4.89 mg/kg bw/day), low-dose quercetin plus Cd-treated group (DQ1) and high-dose quercetin plus Cd-treated group (DQ2). The rats continuously received quercetin and Cd via gavage and drinking water for 12 weeks, respectively. The rat urine samples were collected for metabonomics analysis. Finally, 10 metabolites were identified via the metabonomics profiles of the rat urine samples. Compared with the control group, the intensities of taurine, phosphocreatine, l-carnitine and uric acid were significantly decreased ( p < 0.01) and those of LysoPC (18: 2 (9Z, 12Z)), guanidinosuccinic acid, dopamine, 2,5,7,8-tetramethyl-2(2′-carboxyethyl)-6-hydroxychroman and allantoic acid were significantly increased ( p < 0.01) in the Cd-treated group. However, the intensities of the aforementioned metabolites had restorative changes in the high-dose quercetin plus Cd-treated groups unlike those in Cd-treated group ( p < 0.01 or p < 0.05). Results indicated that quercetin exerts protective effects on Cd-induced toxicity by regulating energy and lipid metabolism, enhancing the antioxidant defence system and protecting liver and kidney function and so on.
تدمد: 1477-0903
0960-3271
DOI: 10.1177/0960327119895811
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5f1eafb2f9315b2b2dd65155514a665
https://doi.org/10.1177/0960327119895811
Rights: CLOSED
رقم الانضمام: edsair.doi.dedup.....f5f1eafb2f9315b2b2dd65155514a665
قاعدة البيانات: OpenAIRE
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