Soluble endothelial adhesion molecules and inflammation markers in patients with β-thalassemia intermedia
| العنوان: | Soluble endothelial adhesion molecules and inflammation markers in patients with β-thalassemia intermedia |
|---|---|
| المؤلفون: | Ioannis Rombos, Maria Tsironi, Periklis Makrythanasis, Antonis Kattamis, Christina Lazaropoulou, Ioannis Papassotiriou, Ino Kanavaki |
| المصدر: | Blood Cells, Molecules, and Diseases. 43:230-234 |
| بيانات النشر: | Elsevier BV, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Adult, Male, congenital, hereditary, and neonatal diseases and abnormalities, Adolescent, Endothelium, medicine.medical_treatment, Splenectomy, Inflammation, Endothelial activation, Young Adult, hemic and lymphatic diseases, Humans, Medicine, In patient, Child, Molecular Biology, business.industry, Cell adhesion molecule, beta-Thalassemia, Cell Biology, Hematology, Middle Aged, medicine.anatomical_structure, Immunology, Molecular Medicine, Female, Intermedia, medicine.symptom, business, Cell Adhesion Molecules, Asymptomatic carrier, Biomarkers |
| الوصف: | The term thalassemia intermedia, indicates a clinical condition of intermediate severity between thalassaemia minor, the asymptomatic carrier, and thalassaemia major, the transfusion-dependent, severe form. Thromboembolic events frequently complicate the outcome of thalassemia intermedia patients, reflecting a hypercoagulable state to which endothelial activation is believed to play an important role. The aim of this study was to evaluate the levels of soluble endothelial adhesion molecules that reflect endothelial activation and dysfunction and levels of chronic inflammation markers in the serum of beta-thalassemia intermedia patients. Thirty-five Greek patients with beta-thalassemia intermedia that have received different types of treatment (Hydroxyurea, splenectomy, untreated), aged 8-63 years, were included in the study. Twenty apparently healthy individuals matched for age and sex, formed the control group. Measurements of sVCAM-1, sICAM-1, sTM, P-selectin, E-selectin and CRP levels were performed using immunoassays. We found that all endothelial adhesion molecules and CRP were significantly increased in patients (p0.001) and not influenced by treatment. A negative correlation was observed between levels of sICAM-1 and sTM and this finding agrees with the results of studies, which propose this correlation as a predictive marker of increased risk for vascular damage. No correlation was observed between endothelial adhesion molecules and inflammation markers. These findings support the hypothesis that a serious degree of endothelial activation and damage along with a state of chronic inflammation underlie the pathophysiology of beta-thalassemia intermedia. Furthermore, these findings are of particular importance in patients who can otherwise be characterized by a subtle clinical phenotype and may have an important role in their clinical care. |
| تدمد: | 1079-9796 |
| DOI: | 10.1016/j.bcmd.2009.06.002 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f47150dfe626b7b71807c12f6c43d7c3 https://doi.org/10.1016/j.bcmd.2009.06.002 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....f47150dfe626b7b71807c12f6c43d7c3 |
| قاعدة البيانات: | OpenAIRE |
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