Post-treatment controllers after treatment interruption in chronically HIV-infected patients
| العنوان: | Post-treatment controllers after treatment interruption in chronically HIV-infected patients |
|---|---|
| المؤلفون: | Laura Comi, Elisa Di Filippo, Franco Maggiolo, Annapaola Callegaro |
| المصدر: | AIDS. 32:623-628 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Cart, Drug, medicine.medical_specialty, Sustained Virologic Response, media_common.quotation_subject, Immunology, HIV Infections, Human leukocyte antigen, CD8-Positive T-Lymphocytes, Cohort Studies, Young Adult, 03 medical and health sciences, Internal medicine, Humans, Immunology and Allergy, Medicine, Genotyping, Aged, media_common, business.industry, virus diseases, HLA-DR Antigens, Viral Load, Discontinuation, Chronic infection, Treatment Outcome, 030104 developmental biology, Infectious Diseases, Anti-Retroviral Agents, Italy, Withholding Treatment, DNA, Viral, Female, HLA-B35 Antigen, business, Viral load, After treatment |
| الوصف: | OBJECTIVE Control HIV replication requires continuous combined antiretroviral therapy (cART) as discontinuation of cART results in a rapid viral rebound. However, a few individuals exist who took cART for several years and did not show the expected viral rebound after treatment cessation. Most post-treatment controllers (PTCs) are early treated individuals. We report three cases who started cART during chronic infection. DESIGN Patients were treated and monitored according to Italian guidelines. For the description of cases, the percentage of CD8CD38HLA*DR cells, CD8CD38HLA*DR cells, major histocompatibility complex genotyping, total HIV-DNA and plasma levels of anti-retroviral (ARV) drugs were performed. RESULTS Patients started therapy during chronic infection. Patient 26636 started her first ARV drug two years after diagnosis and patients 93016 and 50293 started cART with high viral loads and low CD4 cell counts. Time without cART was 13, 11 and 1.5 years, respectively. None presented any of the protective class I HLA alleles and patient 93016 has the HLA-B*35 allele that appears to be enriched in PTCs. Patients 93016 and 50293 had very low levels of CD8CD38HLA*DR cells ( |
| تدمد: | 0269-9370 |
| DOI: | 10.1097/qad.0000000000001743 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3780169e669c90cb08666b3fbc6add4 https://doi.org/10.1097/qad.0000000000001743 |
| رقم الانضمام: | edsair.doi.dedup.....f3780169e669c90cb08666b3fbc6add4 |
| قاعدة البيانات: | OpenAIRE |
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