LIPID PEROXIDATION AND ANTIOXIDANT STATUS IN ß-THALASSEMIA
| العنوان: | LIPID PEROXIDATION AND ANTIOXIDANT STATUS IN ß-THALASSEMIA |
|---|---|
| المؤلفون: | Adalet Meral, Ünsal Günay, Resul Özbek, E. Ozturk, Pinar Tuncel, Esma Sürmen-Gür |
| المساهمون: | Uludağ Üniversitesi/ Tıp Fakültesi/Pediatrik Hematoloji Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı., Meral, Adalet, Gür, Esma Sürmen, Özbek, Resul, Öztürk, Ercan, Günay, Ünsal, AAG-7327-2021 |
| المصدر: | Pediatric Hematology and Oncology. 17:687-693 |
| بيانات النشر: | Informa UK Limited, 2000. |
| سنة النشر: | 2000 |
| مصطلحات موضوعية: | Male, Hemolytic anemia, medicine.medical_specialty, Erythrocytes, Iron Overload, Antioxidant, Adolescent, Iron, medicine.medical_treatment, medicine.disease_cause, Pediatrics, Antioxidants, Superoxide dismutase, Lipid peroxidation, chemistry.chemical_compound, hemic and lymphatic diseases, Internal medicine, medicine, TBARS, Humans, Child, Vitro oxidative stress, chemistry.chemical_classification, Glutathione Peroxidase, Anemia, Iron-Deficiency, biology, Superoxide Dismutase, business.industry, Glutathione peroxidase, beta-Thalassemia, Infant, Anemia, Hematology, medicine.disease, Endocrinology, Oncology, Iron-deficiency anemia, chemistry, Susceptibility, Child, Preschool, Pediatrics, Perinatology and Child Health, Immunology, biology.protein, Antioxidant enzymes, Female, Lipid Peroxidation, business, Oxidative stress, Iron-deficiency |
| الوصف: | Autoxidation of globin chains and iron overload are the suggested mechanisms for the increased oxidative stress in beta -thalassemia. The aim of this study was to evaluated the extend of lipid peroxidation and antioxidant status of patients with beta -thalassemia and iron deficiency anemia (IDA) and compare the results with healthy subjects. Oxidant and antioxidant status of the children with beta -thalassemia major (n = 22) and iron deficiency anemia (n = 19) were studied. Healthy controls (n=14) were age and sex matched. Fresh anticoagulant venous blood samples obtained from all children. Conjugated diene (CD) and thiobarbituric acid-reactive (TBARS) substances were analysed to indicate the oxidative parameters, whereas the erythrocyte superoxide dismutase (SOD) and gluthathione peroxidase (GPx) were measured to show the antioxidant status of the children. Plasma TBARS and CD concentrations in TBARs was significant. In the iron-deficiency group both TBARS and CD concentrations were elevated in beta -thalassemia compared to IDA. When compared to the controls, elevation in TBARS was significant. In the iron-deficiency group both TBARS and CD levels were decreased in TBARS was significant. In the iron-deficiency group both TBARS and CD levels were decreased compared to the controls. SOD and GPx activities were increased in the beta -thalassemia group. SOD in beta -thalassemia was higher than both IDA and the controls and GPx activity was higher than the IDA group. In vivo lipid peroxidation was increased in children with beta -thalassemia major. This leads to a compensatory increase in antioxidant enzymes, whereas IDA does not lead to lipid peroxidation with a normal antioxidant enzyme activity. |
| تدمد: | 1521-0669 0888-0018 |
| DOI: | 10.1080/08880010050211402 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb90cad4e0d791b85ab496b2a4ed073a https://doi.org/10.1080/08880010050211402 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....eb90cad4e0d791b85ab496b2a4ed073a |
| قاعدة البيانات: | OpenAIRE |
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