Patch clamping by numbers
| العنوان: | Patch clamping by numbers |
|---|---|
| المؤلفون: | Christine Williams, Gareth Waldron, Claire Margaret Wood |
| المصدر: | Drug Discovery Today. 9:434-441 |
| بيانات النشر: | Elsevier BV, 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Pharmacology, Patch-Clamp Techniques, Computer science, Drug discovery, Biomedical Technology, Nanotechnology, Computational biology, Ion Channels, Drug Design, Drug Discovery, Animals, Patch clamp, Throughput (business), Ion channel |
| الوصف: | Many ion channels are recognized as amenable targets for a range of disease states and conditions. However, the process of discovering drugs is highly influenced by the chemical doability, the biological confidence in rationale of the approach and the ‘screenability’. To date, the absence of informative high throughput technologies for ion channel screening has resulted in ion channels remaining a largely unexplored class of drug targets. This, however, is about to change – a large increase in the number of data points per day should be achieved by the introduction of automated ‘high throughput’ patch clamp machines. |
| تدمد: | 1359-6446 |
| DOI: | 10.1016/s1359-6446(04)03064-8 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8dfcc1d170044ce53cf6002668cc768 https://doi.org/10.1016/s1359-6446(04)03064-8 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....d8dfcc1d170044ce53cf6002668cc768 |
| قاعدة البيانات: | OpenAIRE |
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