Is cellular energy monitoring more responsive to hypoxia than pulse oximetry?
| العنوان: | Is cellular energy monitoring more responsive to hypoxia than pulse oximetry? |
|---|---|
| المؤلفون: | Liza H. Ashbrook, Aric A. Prather, Andrew D. Krystal, Guy M. Hatch |
| المصدر: | Sleep & breathing = Schlaf & Atmung, vol 24, iss 4 Sleep & Breathing = Schlaf & Atmung |
| بيانات النشر: | eScholarship, University of California, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Clinical Sciences, Respiratory System, Pilot Projects, Polysomnography, Primary snoring, 03 medical and health sciences, Wearable Electronic Devices, 0302 clinical medicine, Sleep Apnea Syndromes, Internal medicine, medicine, Humans, Cellular hypoxia, Psychology, Exertion, Oximetry, Hypoxia, Aged, Monitoring, Physiologic, medicine.diagnostic_test, business.industry, Sleep disordered breathing, Sleep Breathing Physiology and Disorders • Original Article, Blood flow, Cellular hyperoxia, Hypoxia (medical), Middle Aged, medicine.disease, Obstructive sleep apnea, Pulse oximetry, 030228 respiratory system, Otorhinolaryngology, Cardiology, Arterial blood, Female, Neurology (clinical), medicine.symptom, business, Energy Metabolism, Hypopnea, 030217 neurology & neurosurgery, Cellular energy monitor |
| الوصف: | Purpose Pulse oximetry is the current standard for detecting drops in arterial blood oxygen saturation (SpO2) associated with obstructive sleep apnea and hypopnea events in polysomnographic (PSG) testing. However, cellular energy monitoring (CE monitoring), a measure related to cellular hypoxia in the skin, is likely to be more responsive to inadequate breathing during sleep because during hypoxic challenge, such as occurs during apneic events, regulatory mechanisms restrict blood flow to the skin to preferentially maintain SpO2 for more vital organs. We carried out initial proof of concept testing to determine if CE monitoring has promise for being more responsive to hypoxic challenge occurring during sleep-disordered breathing (SDB) than pulse oximetry. Methods We assessed both CE monitoring and pulse oximetry in a series of conditions which affect oxygen supply: (1) breathing nitrogen or 100% oxygen, (2) physical exertion, and (3) studying a night of sleep in an individual known to be a loud snorer. We also present the results of a preliminary study comparing CE monitoring to pulse oximetry in eight individuals undergoing standard clinical overnight polysomnography for suspected SDB. Results CE monitoring is responsive to changes in cellular oxygen supply to the skin and detects hypoxia during SDB events that is not detected by pulse oximetry. Conclusion CE monitoring is a promising tool for identifying pathology at the mild end of the SDB spectrum. |
| وصف الملف: | application/pdf |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d85d4a0a3e45488b3b45840597fadfd2 https://escholarship.org/uc/item/7wd6261j |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d85d4a0a3e45488b3b45840597fadfd2 |
| قاعدة البيانات: | OpenAIRE |
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However, cellular energy monitoring (CE monitoring), a measure related to cellular hypoxia in the skin, is likely to be more responsive to inadequate breathing during sleep because during hypoxic challenge, such as occurs during apneic events, regulatory mechanisms restrict blood flow to the skin to preferentially maintain SpO2 for more vital organs. We carried out initial proof of concept testing to determine if CE monitoring has promise for being more responsive to hypoxic challenge occurring during sleep-disordered breathing (SDB) than pulse oximetry. Methods We assessed both CE monitoring and pulse oximetry in a series of conditions which affect oxygen supply: (1) breathing nitrogen or 100% oxygen, (2) physical exertion, and (3) studying a night of sleep in an individual known to be a loud snorer. We also present the results of a preliminary study comparing CE monitoring to pulse oximetry in eight individuals undergoing standard clinical overnight polysomnography for suspected SDB. Results CE monitoring is responsive to changes in cellular oxygen supply to the skin and detects hypoxia during SDB events that is not detected by pulse oximetry. 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