Reelin central fragment supplementation improves cognitive deficits in a mouse model of Fragile X Syndrome
| العنوان: | Reelin central fragment supplementation improves cognitive deficits in a mouse model of Fragile X Syndrome |
|---|---|
| المؤلفون: | Nicole K, Morrill, Aurelie, Joly-Amado, Qingyou, Li, Sahana, Prabhudeva, Edwin J, Weeber, Kevin R, Nash |
| المصدر: | Experimental Neurology. 357:114170 |
| بيانات النشر: | Elsevier BV, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Mice, Knockout, Disease Models, Animal, Fragile X Mental Retardation Protein, Mice, Cognition, Developmental Neuroscience, Neurology, Fragile X Syndrome, Dietary Supplements, Animals |
| الوصف: | Fragile X Syndrome (FXS) is the most common form of inherited intellectual disability and is characterized by autistic behaviors, childhood seizures, and deficits in learning and memory. FXS has a loss of function of the FMR1 gene that leads to a lack of Fragile X Mental Retardation Protein (FMRP) expression. FMRP is critical for synaptic plasticity, spatial learning, and memory. Reelin is a large extracellular glycoprotein essential for synaptic plasticity and numerous neurodevelopmental processes. Reduction in Reelin signaling is implicated as a contributing factor in disease etiology in several neurological disorders, including schizophrenia, and autism. However, the role of Reelin in FXS is poorly understood. We demonstrate a reduction in Reelin in Fmr1 knock-out (KO) mice, suggesting that a loss of Reelin activity may contribute to FXS. We demonstrate here that Reelin signaling enhancement via a single intracerebroventricular injection of the Reelin central fragment into Fmr1 KO mice can profoundly rescue cognitive deficits in hidden platform water maze and fear conditioning, as well as hyperactivity during the open field. Improvements in behavior were associated with rescued levels of post synaptic marker in Fmr1 KO mice when compared to controls. These data suggest that increasing Reelin signaling in FXS could offer a novel therapeutic for improving cognition in FXS. |
| تدمد: | 0014-4886 |
| DOI: | 10.1016/j.expneurol.2022.114170 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce07b5c0e9904b3836f7303a4c062ba1 https://doi.org/10.1016/j.expneurol.2022.114170 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....ce07b5c0e9904b3836f7303a4c062ba1 |
| قاعدة البيانات: | OpenAIRE |
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