In Vitro Effects of Poly-N-Acetyl Glucosamine on the Activation of Platelets in Platelet-Rich Plasma with and without Red Blood Cells
| العنوان: | In Vitro Effects of Poly-N-Acetyl Glucosamine on the Activation of Platelets in Platelet-Rich Plasma with and without Red Blood Cells |
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| المؤلفون: | C. R. Valeri, Rithy Srey, Ragno G, Tilahun D |
| المصدر: | Journal of Trauma: Injury, Infection & Critical Care. 57:S22-S25 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Blood Platelets, medicine.medical_specialty, Erythrocytes, Time Factors, Platelet Function Tests, Drug Evaluation, Preclinical, Platelet Glycoprotein GPIIb-IIIa Complex, Hematocrit, Critical Care and Intensive Care Medicine, Hemostatics, Acetylglucosamine, Fibrin Fibrinogen Degradation Products, chemistry.chemical_compound, Glucosamine, Internal medicine, medicine, Humans, Platelet, Platelet activation, Annexin A5, Whole blood, medicine.diagnostic_test, business.industry, Fibrinogen, Platelet Activation, Blood Coagulation Factors, Peptide Fragments, Thrombelastography, Thromboxane B2, P-Selectin, Red blood cell, medicine.anatomical_structure, Endocrinology, Platelet Glycoprotein GPIb-IX Complex, chemistry, Platelet-rich plasma, Factor X, Immunology, Prothrombin, Surgery, business |
| الوصف: | BACKGROUND: This study was performed to assess the effect of poly-N-acetyl glucosamine fiber slurry on plasma clotting proteins, platelets, and red blood cells in the clotting of the blood. METHODS: Citrate phosphate dextrose whole blood was stored at 22degreesC for 48 hours to prepare platelet-poor plasma, platelet-rich plasma (PRP), and PRP plus red blood cells with hematocrit values of 20%, 35%, and 45% with and without an equal volume of poly-N-acetyl glucosamine fibers (1 mg/mL 0.9% NaCl). RESULTS: Thromboelastogram data show that poly-N-acetyl glucosamine fibers (p-GlcNAc) significantly reduced the R time in platelet-poor plasma, PRP, and PRP supplemented with red blood cells. Poly-N-acetyl glucosamine fibers increased, but not significantly, Annexin V and factor X binding to platelets, platelet microparticles, and red blood cell Annexin V binding. Poly-N-acetyl glucosamine fibers increased the production of thromboxane B2 by PRP. CONCLUSION: Poly-N-acetyl glucosamine slurry activates platelets. |
| تدمد: | 0022-5282 |
| DOI: | 10.1097/01.ta.0000136744.12440.47 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc53e8b26ce271ead70782f5de786e8c https://doi.org/10.1097/01.ta.0000136744.12440.47 |
| رقم الانضمام: | edsair.doi.dedup.....cc53e8b26ce271ead70782f5de786e8c |
| قاعدة البيانات: | OpenAIRE |
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