Stem cell-based therapeutic strategies for cartilage defects and osteoarthritis
| العنوان: | Stem cell-based therapeutic strategies for cartilage defects and osteoarthritis |
|---|---|
| المؤلفون: | Cosimo De Bari, Anke J. Roelofs |
| المصدر: | Current Opinion in Pharmacology. 40:74-80 |
| بيانات النشر: | Elsevier BV, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Cartilage, Articular, 0301 basic medicine, Osteoarthritis, Chondrocyte, 03 medical and health sciences, 0302 clinical medicine, Drug Discovery, medicine, Animals, Humans, Regeneration, Progenitor cell, Autologous chondrocyte implantation, Pharmacology, 030222 orthopedics, business.industry, Cartilage, Mesenchymal stem cell, Recovery of Function, medicine.disease, Chondrogenesis, Treatment Outcome, 030104 developmental biology, medicine.anatomical_structure, Cancer research, Stem cell, business, Signal Transduction, Stem Cell Transplantation |
| الوصف: | The gold standard cell therapy for repair of articular cartilage defects is autologous chondrocyte implantation, with good outcomes long-term. Mesenchymal stromal/stem cells (MSCs) from bone marrow or connective tissues such as fat are being pursued as alternatives for cartilage repair, and are trialled via intra-articular administration in patients with knee osteoarthritis. Early-phase clinical studies concur on safety and provide some promising insight into efficacy, but the mechanism of action remains unclear. Recent studies implicate extracellular vesicles as important mediators of MSC action, offering exciting therapeutic prospects. Our increasing understanding of the mechanisms underlying intrinsic articular cartilage maintenance and repair fosters hope that novel/repurposed therapeutics could elicit repair through activation of endogenous stem/progenitor cells to maintain healthy joints and prevent osteoarthritis. |
| تدمد: | 1471-4892 |
| DOI: | 10.1016/j.coph.2018.03.009 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8ff8aff8d6de2761c87617be529b3ee https://doi.org/10.1016/j.coph.2018.03.009 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c8ff8aff8d6de2761c87617be529b3ee |
| قاعدة البيانات: | OpenAIRE |
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