Volume and neuron number of the mediodorsal thalamic nucleus in schizophrenia: a replication study
| العنوان: | Volume and neuron number of the mediodorsal thalamic nucleus in schizophrenia: a replication study |
|---|---|
| المؤلفون: | Bruno Baumann, Hans Gert Bernstein, Andrea Schmidt, Bernhard Bogerts, Peter Danos, Renate Stauch, Dieter Krell, Georg Northoff |
| المصدر: | Psychiatry research. 140(3) |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Adult, Male, Psychosis, Mediodorsal Thalamic Nucleus, Central nervous system, Thalamus, Neuroscience (miscellaneous), Cell Count, Neuropathology, medicine, Humans, Radiology, Nuclear Medicine and imaging, Aged, Neurons, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Numero sign, Diagnostic and Statistical Manual of Mental Disorders, Psychiatry and Mental health, medicine.anatomical_structure, Schizophrenia, Brain size, Female, Neuron, Autopsy, Psychology, Neuroscience |
| الوصف: | Previous neuropathological studies on the mediodorsal thalamic nucleus (MD) in schizophrenia have yielded conflicting results. While some studies suggested that patients with schizophrenia have a pronounced reduction of the volume and neuron number in the MD, more recent data have not found anatomical alterations in this thalamic nucleus. However, most studies have considerable methodological shortcomings. In the present study, we investigated the volume, neuron density and neuron number in the left and right MD in patients with schizophrenia (n=20) and normal control subjects without neuropsychiatric disorders (n=18). Patients with schizophrenia showed no significant difference in neuron density and total neuron number in the MD. Compared with the control group, patients with schizophrenia had a smaller MD volume in both hemispheres, a difference that approached significance in the left MD (-7.3%) when the whole brain volume was included as a covariate. No significant main group effect of diagnosis was found for the right MD volume. There were no significant correlations between MD volume, neuron density, total neuron number and the duration of illness or the age of the patients. Taken together, the present results suggest that schizophrenia is associated with a moderate volume reduction in the left mediodorsal thalamic nucleus, while the neuron density and the total neuron number are unchanged. |
| تدمد: | 0165-1781 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5abc435235856e15a2e9a4f036b98e4 https://pubmed.ncbi.nlm.nih.gov/16297604 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....c5abc435235856e15a2e9a4f036b98e4 |
| قاعدة البيانات: | OpenAIRE |
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