MicroRNA‐based risk scoring system to identify early‐stage oral squamous cell carcinoma patients at high‐risk for cancer‐specific mortality
| العنوان: | MicroRNA‐based risk scoring system to identify early‐stage oral squamous cell carcinoma patients at high‐risk for cancer‐specific mortality |
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| المؤلفون: | Brenda Y. Hernandez, Claire R. Stewart, Regina M. Santella, Dominic LaRoche, Angela J. Yoon, Tian Wang, Bradley D. McDowell, Fatemeh Momen-Heravi, Richard D. Carvajal, Shuang Wang, David I. Kutler, Scott M. Peters, Elizabeth Philipone |
| المصدر: | Head Neck |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, medicine.medical_specialty, Multivariate statistics, TNM staging system, Article, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, microRNA, Biomarkers, Tumor, medicine, Humans, Grading (tumors), Neoplasm Staging, Framingham Risk Score, Squamous Cell Carcinoma of Head and Neck, business.industry, Proportional hazards model, Hazard ratio, Prognosis, Confidence interval, MicroRNAs, 030104 developmental biology, Otorhinolaryngology, Head and Neck Neoplasms, 030220 oncology & carcinogenesis, Carcinoma, Squamous Cell, Mouth Neoplasms, Neoplasm Recurrence, Local, business |
| الوصف: | BACKGROUND: For early-stage oral squamous cell carcinoma (OSCC), there is no existing risk-stratification modality beyond conventional TNM staging system to identify patients at high risk for cancer-specific mortality. METHODS: A total of 568 early-stage OSCC patients who had surgery only and also with available 5-year clinical outcomes data were identified. Signature microRNAs (miRNAs) were discovered using deep sequencing analysis and validated by qRT-PCR. The final 5-plex prognostic marker panel was utilized to generate a cancer-specific mortality risk score using the multivariate Cox regression analyses. The prognostic markers were validated in the internal and external validation cohorts. RESULTS: The risk score from the 5-plex marker panel consisting of miRNAs-127-3p, 4736, 655-3p, TNM stage and histologic grading stratified patients into four risk categories. Compared to the low-risk group, the high-risk group had 23-fold increased mortality risk (hazard ratio 23, 95% confidence interval 13-42), with a median time-to-recurrence of 6 months and time-to-death of 11 months (vs >60 months for each among low-risk patient; p < .001). CONCLUSION: The miRNA-based 5-plex marker panel driven mortality risk score formula provides clinically practical and reliable measures to assess the prognosis of patients assigned to an early-stage OSCC. |
| تدمد: | 1097-0347 1043-3074 |
| DOI: | 10.1002/hed.26089 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3f8506b5804a842ad368526c6936f70 https://doi.org/10.1002/hed.26089 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c3f8506b5804a842ad368526c6936f70 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10970347 10433074 |
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| DOI: | 10.1002/hed.26089 |