Logic of a mammalian metabolic cycle: an oscillated NAD+/NADH redox signaling regulates coordinated histone expression and S-phase progression
| العنوان: | Logic of a mammalian metabolic cycle: an oscillated NAD+/NADH redox signaling regulates coordinated histone expression and S-phase progression |
|---|---|
| المؤلفون: | Yan Luo, Shuang Ru Goh, Fa-Xing Yu, Lei Zheng, Ru-Ping Dai |
| المصدر: | Cell cycle (Georgetown, Tex.). 8(5) |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Cyclin E, Article, S Phase, Histones, Cell Line, Tumor, Humans, Molecular Biology, chemistry.chemical_classification, Reactive oxygen species, biology, Cyclin-dependent kinase 2, Cell Cycle, Cyclin-Dependent Kinase 2, DNA replication, Cell Biology, Cell cycle, NAD, Cell biology, Histone, Biochemistry, chemistry, biology.protein, NAD+ kinase, Signal transduction, Oxidation-Reduction, Developmental Biology, HeLa Cells, Signal Transduction |
| الوصف: | Many biological activities naturally oscillate. Here, we show that the NAD(+)/NADH ratios (redox status) fluctuate during mammalian cell cycle, with the S-phase redox status being the least oxidative. The S-phase NAD(+)/NADH redox status gates histone expression and S-phase progression, and may provide a genome protection mechanism during S-phase DNA replication as implicated in yeast. Accordingly, perturbing the cellular redox inhibits histone expression and leads to S-phase arrest. We propose that the S-phase NAD(+)/NADH redox status constitutes a redox signaling, which along with the cyclin E/cdk2 signaling regulates histone expression and S-phase progression. |
| تدمد: | 1551-4005 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0f175f0971177a0426413d5df5200e4 https://pubmed.ncbi.nlm.nih.gov/19221488 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c0f175f0971177a0426413d5df5200e4 |
| قاعدة البيانات: | OpenAIRE |
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