Discovery of 6-[4-(6-nitroxyhexanoyl)piperazin-1-yl)]-9H-purine, as pharmacological post-conditioning agent
| العنوان: | Discovery of 6-[4-(6-nitroxyhexanoyl)piperazin-1-yl)]-9H-purine, as pharmacological post-conditioning agent |
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| المؤلفون: | Anastasia Zoga, Efstathios K. Iliodromitis, Theano Fotopoulou, S.I. Bibli, Dimitrios Th. Kremastinos, Ioanna Andreadou, Maria Koufaki |
| المصدر: | Bioorganic & Medicinal Chemistry. 20:5948-5956 |
| بيانات النشر: | Elsevier BV, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Purine, Cardiotonic Agents, Clinical Biochemistry, Myocardial Infarction, Pharmaceutical Science, Post conditioning, Purine analogue, Endogeny, 030204 cardiovascular system & hematology, Pharmacology, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Drug Discovery, Animals, Ischemic Postconditioning, Molecular Biology, 030304 developmental biology, 0303 health sciences, Nitrates, Chemistry, Myocardium, Organic Chemistry, Hemodynamics, Heart, Infarct size, 3. Good health, Purines, Molecular Medicine, Ischemic preconditioning, Rabbits |
| الوصف: | Novel purine analogues bearing nitrate esters were designed and synthesized in an effort to develop compounds triggering endogenous cardioprotective mechanisms such as ischemic preconditioning (IPC) or postconditioning (PostC). The majority of the compounds reduced infarct size compared to the control group in anesthetized rabbits, whereas administration of the most active analogue 16 at a dose of 3.8 μmol/kg resulted on a significant reduction of infarct size, compared to PostC group (13.4 ± 1.9% vs 26.4 ± 2.3%). These findings introduce a novel class of promising pharmacological compounds that could be used as mimics or enhancers of PostC. |
| تدمد: | 0968-0896 |
| DOI: | 10.1016/j.bmc.2012.07.037 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf778734768bcbfd5b0040f11d297d19 https://doi.org/10.1016/j.bmc.2012.07.037 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....bf778734768bcbfd5b0040f11d297d19 |
| قاعدة البيانات: | OpenAIRE |
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