The Arabidopsis Chromatin-Remodeling Factor CHR5 Regulates Plant Immune Responses and Nucleosome Occupancy
| العنوان: | The Arabidopsis Chromatin-Remodeling Factor CHR5 Regulates Plant Immune Responses and Nucleosome Occupancy |
|---|---|
| المؤلفون: | Yuan Ding, Jian Hua, Baohong Zou, Qi Sun, Dong-Lei Yang, Wenli Zhang, Zhenying Shi |
| المصدر: | Plantcell physiology. 58(12) |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Physiology, Histone monoubiquitination, Ubiquitin-Protein Ligases, Arabidopsis, Chromatin Remodeling Factor, NLR Proteins, Plant Science, 03 medical and health sciences, Gene Expression Regulation, Plant, Botany, Arabidopsis thaliana, Plant Immunity, Plant Diseases, biology, Arabidopsis Proteins, Calcium-Binding Proteins, Membrane Proteins, Cell Biology, General Medicine, biology.organism_classification, Chromatin Assembly and Disassembly, Plants, Genetically Modified, Chromatin, Cell biology, Nucleosomes, DNA-Binding Proteins, 030104 developmental biology, Histone, Multigene Family, DNA methylation, Mutation, biology.protein, Body region, Carrier Proteins, Transcription Factors |
| الوصف: | ATP-dependent chromatin-remodeling factors use the energy of ATP hydrolysis to alter the structure of chromatin and are important regulators of eukaryotic gene expression. One such factor encoded by CHR5 (Chromatin-Remodeling Factor 5) in Arabidopsis (Arabidopsis thaliana) was previously found to be involved in regulation of growth and development. Here we show that CHR5 is required for the up-regulation of the intracellular immune receptor gene SNC1 (SUPPRESSOR OF npr1-1, CONSTITUTIVE1) and consequently the autoimmunity induced by SNC1 up-regulation. CHR5 functions antagonistically with another chromatin-remodeling gene DDM1 (DECREASED DNA METHYLATION 1) and independently with a histone mono-ubiquitinase HUB1 (HISTONE MONOUBIQUITINATION 1) in SNC1 regulation. In addition, CHR5 is a positive regulator of SNC1-independent plant immunity against the bacterial pathogen Pseudomonas syringae. Furthermore, the chr5 mutant has increased nucleosome occupancy in the promoter region relative to the gene body region at the whole-genome level, suggesting a global role for CHR5 in remodeling nucleosome occupancy. Our study thus establishes CHR5 as a positive regulator of plant immune responses including the expression of SNC1 and reveals a role for CHR5 in nucleosome occupancy which probably impacts gene expression genome wide. |
| تدمد: | 1471-9053 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf57f3f341d77b821dd71e6825843054 https://pubmed.ncbi.nlm.nih.gov/29048607 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bf57f3f341d77b821dd71e6825843054 |
| قاعدة البيانات: | OpenAIRE |
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