Prognostic significance of quantitative measures of myocardial infarct pathology using native T1 mapping, in survivors of ST-elevation myocardial infarction
| العنوان: | Prognostic significance of quantitative measures of myocardial infarct pathology using native T1 mapping, in survivors of ST-elevation myocardial infarction |
|---|---|
| المؤلفون: | Aleksandra Radjenovic, Mitchell Lindsay, Margaret McEntegart, Ian Ford, David Carrick, Stuart Watkins, Samuli M Rauhalammi, Colin Berry, Caroline Haig, Mark C. Petrie, Stuart Hood, Ahmed Marous, Hany Eteiba, Keith G. Oldroyd, Ify Mordi, Niko Tzemos, Nadeem Ahmed |
| المصدر: | Journal of Cardiovascular Magnetic Resonance |
| بيانات النشر: | BioMed Central, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Medicine(all), medicine.medical_specialty, Ejection fraction, Radiological and Ultrasound Technology, business.industry, Hazard ratio, medicine.disease, equipment and supplies, Internal medicine, Heart failure, medicine, Cardiology, cardiovascular system, Oral Presentation, Radiology, Nuclear Medicine and imaging, Myocardial infarction, cardiovascular diseases, Cardiology and Cardiovascular Medicine, Ventricular remodeling, business, human activities, TIMI, Killip class, Angiology |
| الوصف: | Background: Myocardial longitudinal relaxation time (T1, ms) is a fundamental magnetic property of tissue that is related to water content and mobility. The pathophysiological and prognostic importance of native myocardial T1 values in acute STEMI patients is unknown. We aimed to assess the clinical significance of infarct tissue characteristics using native T1 cardiac magnetic resonance (CMR).\ud \ud Methods: We performed a prospective single center cohort study in reperfused STEMI patients who underwent CMR 2 days and 6 months post-MI. Native T1 CMR (MOLLI investigational prototype sequence: 3 (3) 3 (3) 5) was measured in myocardial regions-of-interest. The area-at-risk and infarct territory were depicted with T1 mapping and late gadolinium contrast enhancement imaging, respectively. All-cause death or heart failure hospitalization was a pre-specified outcome that was assessed during follow-up.\ud \ud Results: 300 STEMI patients (mean±SD age 59±12 years, 74% male, 114 with anterior STEMI) gave informed consent and had CMR (14 July 2011 - 22 November 2012). Of these, 288 STEMI patients had evaluable T1 maps and follow-up assessments (median duration 845 days). Infarct size was 18 ±14% of left ventricular mass. Microvascular obstruction occurred in 160 (55.6%) patients. Native T1 within the area-at-risk (1097 ±52 ms) was higher than in the remote zone (961 ±25 ms; p |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1097-6647 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdd6688adbfb6fd5525e8e8ad4bd53a2 https://eprints.gla.ac.uk/104056/1/104056.pdf |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bdd6688adbfb6fd5525e8e8ad4bd53a2 |
| قاعدة البيانات: | OpenAIRE |
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The pathophysiological and prognostic importance of native myocardial T1 values in acute STEMI patients is unknown. We aimed to assess the clinical significance of infarct tissue characteristics using native T1 cardiac magnetic resonance (CMR).\ud \ud Methods: We performed a prospective single center cohort study in reperfused STEMI patients who underwent CMR 2 days and 6 months post-MI. Native T1 CMR (MOLLI investigational prototype sequence: 3 (3) 3 (3) 5) was measured in myocardial regions-of-interest. The area-at-risk and infarct territory were depicted with T1 mapping and late gadolinium contrast enhancement imaging, respectively. All-cause death or heart failure hospitalization was a pre-specified outcome that was assessed during follow-up.\ud \ud Results: 300 STEMI patients (mean±SD age 59±12 years, 74% male, 114 with anterior STEMI) gave informed consent and had CMR (14 July 2011 - 22 November 2012). Of these, 288 STEMI patients had evaluable T1 maps and follow-up assessments (median duration 845 days). Infarct size was 18 ±14% of left ventricular mass. Microvascular obstruction occurred in 160 (55.6%) patients. 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