Effect of serotonin (5-HT) on trigeminal rhythmic activities generated in in vitro brainstem block preparations
| العنوان: | Effect of serotonin (5-HT) on trigeminal rhythmic activities generated in in vitro brainstem block preparations |
|---|---|
| المؤلفون: | Hidehiko Koizumi, Susumu Tanaka, Mikihiko Kogo, Akifumi Enomoto, K. Ishihama, T. Matsuya, Atsuyuki Mori |
| المصدر: | Journal of dental research. 81(9) |
| سنة النشر: | 2002 |
| مصطلحات موضوعية: | 0301 basic medicine, Agonist, Serotonin, Superior Colliculi, N-Methylaspartate, medicine.drug_class, Statistics as Topic, Stimulation, Biology, Bicuculline, Synaptic Transmission, Trigeminal Nuclei, Piperazines, GABA Antagonists, Rats, Sprague-Dawley, 03 medical and health sciences, 0302 clinical medicine, Neural Pathways, medicine, Excitatory Amino Acid Agonists, Animals, Trigeminal Nerve, General Dentistry, Electrodes, 5-HT receptor, Motor Neurons, Fourth Ventricle, 030102 biochemistry & molecular biology, Methysergide, Superior colliculus, Signal Processing, Computer-Assisted, 030206 dentistry, Anatomy, Inferior Colliculi, Rats, Serotonin Receptor Agonists, Indophenol, Animals, Newborn, Receptors, Serotonin, 5-HT1A receptor, Brainstem, Serotonin Antagonists, Neuroscience, medicine.drug, Brain Stem |
| الوصف: | We used rat isolated brainstem block preparations to analyze the functional roles of serotonin receptors in the generation of trigeminal rhythmic activities. We previously reported that trigeminal rhythmic activities could be induced by some pharmacological applications in an isolated brainstem preparation with a rostral boundary at the border between the inferior and superior colliculus, and a caudal border at the level of the rostral facial nucleus. However, the same stimulation did not induce trigeminal rhythmic activities in a whole brainstem block preparation with the same rostral boundary and a caudal border at the obex level. In the present study, both the 5-HT1Aphthalimido-butyl-piperazine, and the 5-HT2Cagonist, 1-2,5-dimethoxy-4-iodophenyl-2-aminopropane, combined with N-methyl-D,L-aspartate and bicuculline, elicited trigeminal rhythmic activities in a whole brainstem block preparation. Our results suggest that serotonin has both facilitation and inhibition effects on the generation of trigeminal rhythmic activities in an isolated brainstem block preparation in vitro. |
| تدمد: | 0022-0345 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b488aef31c951763b4b5e4293dd18ea1 https://pubmed.ncbi.nlm.nih.gov/12202639 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....b488aef31c951763b4b5e4293dd18ea1 |
| قاعدة البيانات: | OpenAIRE |
كن أول من يترك تعليقا!