Bone regenerative potential of modified biphasic graft materials
| العنوان: | Bone regenerative potential of modified biphasic graft materials |
|---|---|
| المؤلفون: | Matthew Breit, Rehan Khan, Dinely Colon, Malvin N. Janal, Paulo G. Coelho, Lukasz Witek, Ryo Jimbo, Nick Tovar |
| المصدر: | Implant dentistry. 24(2) |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | medicine.medical_specialty, Materials science, Bone Regeneration, Bone Transplantation, Polymers, Skull, Rabbit (nuclear engineering), Calvaria, Surgery, Bone ingrowth, surgical procedures, operative, medicine.anatomical_structure, Durapatite, Bone Substitutes, medicine, Animals, Collagen, Rabbits, Oral Surgery, Synthetic bone graft, Biomedical engineering |
| الوصف: | To investigate the bone regenerative effect of polymer and collagen incorporation to synthetic bone graft materials.The bone ingrowth of biphasic graft materials was tested in a rabbit calvaria defect model after chemical characterization: HA/TCP (25%/75%) with collagen, HA/TCP (25%/75%) without collagen, (HA/TCP)/PLGA (85%/15%) with collagen, (HA/TCP)/PLGA (65%/35%) with collagen and a commercially available (HA/TCP)/PLGA (50%/50%) (ReOss™, Intra-Lock International, Boca Raton, FL) was used as control. After 4 and 8 weeks, the retrieved samples were subjected to histomorphometrical analysis.Histomorphometry presented no significant differences concerning the bone formation between the different groups at both 4 and 8 weeks. Evidently, the (HA/TCP)/PLGA (65%/35%) with collagen presented the least amount of soft tissue incorporation within the defect. The same group possessed higher amounts of bone graft material within the defect throughout the 8-week observation period, whereas the other groups seemed to decrease in volume from 4 to 8 weeks.Changing the PLGA percentage to 35% within the biphasic graft material seemed to maintain its volume and prevented soft tissue migration, which could be clinically beneficial. |
| تدمد: | 1538-2982 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1e084601067d28c2e1ec078cbd61187 https://pubmed.ncbi.nlm.nih.gov/25734946 |
| رقم الانضمام: | edsair.doi.dedup.....b1e084601067d28c2e1ec078cbd61187 |
| قاعدة البيانات: | OpenAIRE |
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