Outcome of very elderly chronic myeloid leukaemia patients treated with imatinib frontline
| العنوان: | Outcome of very elderly chronic myeloid leukaemia patients treated with imatinib frontline |
|---|---|
| المؤلفون: | Fabio Stagno, Patrizia Pregno, Alessandra Iurlo, Nicola Orofino, Gianfranco Giglio, Cristina Bucelli, Giovanna Mansueto, Massimiliano Bonifacio, Francesca Celesti, Elisabetta Abruzzese, Ester Orlandi, Antonella Russo-Rossi, Luigiana Luciano, Adam D'Addosio, Sara Galimberti, Dario Ferrero, Elena Crisà, Monica Crugnola, Gabriele Gugliotta, Enrico Montefusco, Gianantonio Rosti, Giovanna Rege Cambrin, Sergio Storti, Roberto Latagliata, Francesco Cavazzini, Fausto Castagnetti, Michele Cedrone, Mario Tiribelli, Endri Mauro, Antonella Gozzini, Gianni Binotto, Carmen Fava, Franca Falzetti, Mario Annunziata, Elisabetta Calistri, Romano Atelda, Federica Sorà, Nicola Sgherza, Isabella Capodanno, Sabina Russo, Malgorzata Monika Trawinska, Monica Bocchia, Massimo Breccia, Alessandro Isidori |
| المساهمون: | Crugnola M., Castagnetti F., Breccia M., Ferrero D., Trawinska M.M., Abruzzese E., Annunziata M., Stagno F., Tiribelli M., Binotto G., Bonifacio M., Fava C., Iurlo A., Bucelli C., Mansueto G., Gozzini A., Falzetti F., Montefusco E., Crisa E., Gugliotta G., Russo S., Cedrone M., RussoRossi A., Pregno P., Isidori A., Mauro E., Atelda R., Giglio G., Celesti F., Sora F., Storti S., D'Addosio A., Galimberti S., Orlandi E., Calistri E., Bocchia M., Cavazzini F., Rege Cambrin G., Orofino N., Luciano L., Sgherza N., Rosti G., Latagliata R., Capodanno I. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Time Factors, medicine.drug_class, Socio-culturale, Tyrosine kinase inhibitor, Blastic Phase, Tyrosine-kinase inhibitor, Chronic myeloid leukaemia, Elderly, Outcome, Tyrosine kinase inhibitor, Chronic myeloid leukaemia, Elderly, Outcome, Disease-Free Survival, Follow-Up Studie, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, 80 and over, medicine, Humans, Chronic, Survival rate, Aged, Aged, 80 and over, Leukemia, Hematology, Settore MED/06 - ONCOLOGIA MEDICA, business.industry, Incidence (epidemiology), Imatinib, General Medicine, Survival Rate, Female, Follow-Up Studies, Imatinib Mesylate, 030220 oncology & carcinogenesis, Concomitant, Toxicity, BCR-ABL Positive, business, Myelogenous, 030215 immunology, medicine.drug, Human |
| الوصف: | Very elderly (> 75years) chronic myeloid leukaemia (CML) patients at diagnosis are sometimes treated with different doses of imatinib (IM) based on concomitant diseases and physicians’ judgement. However, data on long-term follow-up of these patients are still lacking. To investigate treatment response and outcome, we retrospectively revised an Italian database of 263 very elderly CML patients receiving IM from the time of diagnosis. Median age at diagnosis was 78.5years and 56% of patients had 2 or 3 comorbidities. A complete haematological and cytogenetic response were achieved in 244 (92.8%) and 184 (69.9%) patients, respectively. In 148 cases (56.2%), a major molecular response was observed, which was deep in 63 cases (24%). A blastic phase occurred in 11 patients (4.2%). After a median follow-up of 45.0months, 93 patients have died (9 from disease progression) and 104 (39.5%) are still in treatment with IM. Incidence of grades 3–4 haematological and non-haematological toxicity was similar to those reported in younger patients. Five-year event-free survival was 54.5% and 45.2% in patients ≤80years and > 80years, respectively (p = 0.098). Five years OS was 75.7% and 61.6% in patients ≤80years and > 80years, respectively (p = 0.003). These findings show that IM plays an important role in frontline treatment of very elderly CML patients without increased toxicity and any effort to treat these patients with standard doses should be made in order to achieve responses as in younger subjects. |
| وصف الملف: | STAMPA |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b02ad806f9a8e21c95f186b2221a76a9 http://hdl.handle.net/11585/739649 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b02ad806f9a8e21c95f186b2221a76a9 |
| قاعدة البيانات: | OpenAIRE |
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