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Challenges posed by non-random missing quality of life data in an advanced-stage colorectal cancer clinical trial

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العنوان: Challenges posed by non-random missing quality of life data in an advanced-stage colorectal cancer clinical trial
المؤلفون: Franco M. Muggia, Christine Upchurch, Barbara McKnight, Cynthia G. Leichman, Laura C. Lovato, Wendy A. James, Julia Sawyers Triplett, Leora Tanaka, Frank L. Meyskens, Carol M. Moinpour, Martha Lennard
المصدر: Moinpour, CM; Triplett, JS; McKnight, B; Lovato, LC; Upchurch, C; Leichman, CG; et al.(2000). Challenges posed by non-random missing quality of life data in an advanced-stage colorectal cancer clinical trial. PSYCHO-ONCOLOGY, 9(4), 340-354. doi: 10.1002/1099-1611(200007/08)9:4<340::AID-PON466>3.3.CO;2-6. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/3314v2s8
بيانات النشر: Wiley, 2000.
سنة النشر: 2000
مصطلحات موضوعية: Gerontology, medicine.medical_specialty, Randomization, business.industry, Colorectal cancer, Experimental and Cognitive Psychology, Context (language use), Disease, Missing data, medicine.disease, humanities, law.invention, Clinical trial, Psychiatry and Mental health, Oncology, Quality of life, Randomized controlled trial, law, Physical therapy, Medicine, business
الوصف: Effects of variations in agent, dose, and route of treatment administration on patient reported quality of life (QOL) were examined for 279 patients enrolled on a seven-arm randomized clinical trial (S8905) of 5-FU and its modulation for advanced colorectal cancer. Patients completed QOL questionnaires at randomization and weeks 6, 11, and 21 post-randomization with five QOL endpoints considered primary: three treatment-specific symptoms (stomatitis, diarrhea, and hand/foot sensitivity); physical functioning; and emotional functioning. Patient compliance with the QOL assessment schedule was good, supporting the feasibility of including QOL measures in cooperative group trials. However, death and deteriorating health produced substantial missing data. Cross-sectional analyses indicated that the seven therapeutic arms did not differ in their impact on QOL. Unfortunately, longitudinal analyses of the QOL data were inappropriate given non-random missing data. Graphical presentation of non-random missing data identified the seriousness of this problem and its effect on potential conclusions about QOL during treatment. This problem appears to be particularly challenging in the context of advanced-stage disease. Failure to recognize the presence of non-random missing data can lead to serious overestimates of patient QOL over time.
وصف الملف: application/pdf
تدمد: 1099-1611
1057-9249
DOI: 10.1002/1099-1611(200007/08)9:4<340::aid-pon466>3.0.co;2-f
DOI: 10.1002/1099-1611(200007/08)9:4<340::AID-PON466>3.3.CO;2-6.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0050fd5a75784cd16d38d85e47cc437
https://doi.org/10.1002/1099-1611(200007/08)9:4<340::aid-pon466>3.0.co;2-f
Rights: OPEN
رقم الانضمام: edsair.doi.dedup.....b0050fd5a75784cd16d38d85e47cc437
قاعدة البيانات: OpenAIRE
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