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DNA methylation at birth and fine motor ability in childhood: an epigenome-wide association study with replication

التفاصيل البيبلوغرافية
العنوان: DNA methylation at birth and fine motor ability in childhood: an epigenome-wide association study with replication
المؤلفون: Fadila Serdarevic, Mannan Luo, Irma Karabegović, Anne-Claire Binter, Silvia Alemany, Ryan Mutzel, Monica Guxens, Mariona Bustamante, Aida Hajdarpasic, Tonya White, Janine F Felix, Charlotte A.M. Cecil, Henning Tiemeier
المساهمون: Institut Català de la Salut, [Serdarevic F] Department of Child and Adolescent Psychiatry, Erasmus MC, University Medical Centre, Rotterdam, the Netherlands. Department of Social and Behavioral Science, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Sarajevo Medical School, Sarajevo School of Science and Technology, Sarajevo, Bosnia and Herzegovina. [Luo M] Department of Child and Adolescent Psychiatry, Erasmus MC, University Medical Centre, Rotterdam, the Netherlands. The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands. Department of Psychology, Education and Child Studies, Erasmus University Rotterdam, Rotterdam, the Netherlands. [Karabegović I] Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands. [Binter AC] ISGlobal, Barcelona, Spain. Universitat Pompeu Fabra, Barcelona, Spain. Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain. [Alemany S] Department of Child and Adolescent Psychiatry, Erasmus MC, University Medical Centre, Rotterdam, the Netherlands. Unitat de Genètica Psiquiàtrica, Grup de Recerca de Psiquiatria, Salut Mental i Addiccions, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain. [Mutzel R] Department of Child and Adolescent Psychiatry, Erasmus MC, University Medical Centre, Rotterdam, the Netherlands, Vall d'Hebron Barcelona Hospital Campus, Child and Adolescent Psychiatry / Psychology, Erasmus MC other, Epidemiology, Radiology & Nuclear Medicine, Pediatrics
المصدر: Scientia
Epigenetics. Landes Bioscience
بيانات النشر: Taylor & Francis, 2023.
سنة النشر: 2023
مصطلحات موضوعية: Cancer Research, Fine motor development, DNA methylation, Infants autistes, trastornos mentales::trastornos del desarrollo neurológico::trastornos generalizados del desarrollo del niño::trastorno del espectro del autismo [PSIQUIATRÍA Y PSICOLOGÍA], Investigative Techniques::Epidemiologic Methods::Epidemiologic Research Design::Genome-Wide Association Study [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], ADN - Metilació, Cord blood, Mental Disorders::Neurodevelopmental Disorders::Child Development Disorders, Pervasive::Autism Spectrum Disorder [PSYCHIATRY AND PSYCHOLOGY], Epigenètica, Chemical Phenomena::Biochemical Phenomena::Alkylation::Methylation::DNA Methylation [PHENOMENA AND PROCESSES], fenómenos químicos::fenómenos bioquímicos::alquilación::metilación::metilación del ADN [FENÓMENOS Y PROCESOS], técnicas de investigación::métodos epidemiológicos::diseño de la investigación epidemiológica::estudio de asociación genómica completa [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Cognitive function, Molecular Biology, EWAS
الوصف: DNA methylation; Cognitive function; Cord blood Metilació de l'ADN; Funció cognitiva; Sang de cordó Metilación del ADN; Función cognitiva; Sangre de cordón Lower fine motor performance in childhood has been associated with poorer cognitive development and neurodevelopmental conditions such as autism spectrum disorder, yet, biological underpinnings remain unclear. DNA methylation (DNAm), an essential process for healthy neurodevelopment, is a key molecular system of interest. In this study, we conducted the first epigenome-wide association study of neonatal DNAm with childhood fine motor ability and further examined the replicability of epigenetic markers in an independent cohort. The discovery study was embedded in Generation R, a large population-based prospective cohort, including a subsample of 924 ~ 1026 European-ancestry singletons with available data on DNAm in cord blood and fine motor ability at a mean (SD) age of 9.8 (0.4) years. Fine motor ability was measured using a finger-tapping test (3 subtests including left-, right-hand and bimanual), one of the most frequently used neuropsychological instruments of fine motor function. The replication study comprised 326 children with a mean (SD) age of 6.8 (0.4) years from an independent cohort, the INfancia Medio Ambiente (INMA) study. Four CpG sites at birth were prospectively associated with childhood fine motor ability after genome-wide correction. Of these, one CpG (cg07783800 in GNG4) was replicated in INMA, showing that lower levels of methylation at this site were associated with lower fine motor performance in both cohorts. GNG4 is highly expressed in the brain and has been implicated in cognitive decline. Our findings support a prospective, reproducible association between DNAm at birth and fine motor ability in childhood, pointing to GNG4 methylation at birth as a potential biomarker of fine motor ability. The EWAS data was funded by a grant from the Netherlands Genomics Initiative (NGI)/Netherlands Organisation for Scientific Research (NWO) Netherlands Consortium for Healthy Aging (NCHA; project nr. 050-060-810), funds from the Genetic Laboratory of the Department of Internal Medicine, Erasmus MC, and a grant from the National Institute of Child and Human Development (R01HD068437). HT was supported by a grant of the Dutch Ministry of Education, Culture, and Science and the Netherlands Organization for Scientific Research (NWO grant No. 024.001.003, Consortium on Individual Development). FS was supported by a Royal Netherlands Academy of Science and Art (KNAW) Van Leersum fellowship. ML is supported by the scholarship from the China Scholarship Council (201706990036). CC is supported by the European Research Council (ERC) under the European Union’s Horizon 2020 Research and Innovation Programme under grant agreements No 101039672 (TEMPO) and No 848158 (EarlyCause). This project received funding from the European Union’s Horizon 2020 research and innovation programme (733206, LifeCycle).The epigenetic studies in INMA were mainly funded by grants from Instituto de Salud Carlos III (Red INMA G03/176, CB06/02/0041, CP18/00018), Spanish Ministry of Health (FIS-PI04/1436, FIS-PI08/1151 including FEDER funds, FIS-PI11/00610, FIS-FEDER-PI06/0867, FIS-FEDER-PI03-1615) Generalitat de Catalunya-CIRIT 1999SGR 00241, Fundació La marató de TV3 (090430), EU Commission (261357-MeDALL: Mechanisms of the Development of ALLergy), and European Research Council (268479-BREATHE: BRain dEvelopment and Air polluTion ultrafine particles in scHool childrEn).
وصف الملف: application/pdf; application/vnd.openxmlformats-officedocument.wordprocessingml.document
اللغة: English
تدمد: 1559-2294
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abb84fbaf9b1b64feaa02fee425dd3d4
https://hdl.handle.net/11351/9492
Rights: OPEN
رقم الانضمام: edsair.doi.dedup.....abb84fbaf9b1b64feaa02fee425dd3d4
قاعدة البيانات: OpenAIRE
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