Drugs Repurposing for Coronavirus Treatment: Computational Study Based On Molecular Topology
| العنوان: | Drugs Repurposing for Coronavirus Treatment: Computational Study Based On Molecular Topology |
|---|---|
| المؤلفون: | Maria Galvez-Llompart, Jorge Galvez, Riccardo Zanni |
| المصدر: | RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir instname RIUCV: Repositorio de la Universidad Católica de Valencia San Vicente Mártir Universidad Católica de Valencia San Vicente Mártir |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.drug_class, Antibiotics, 2415 Biología Molecular, Computational biology, medicine.disease_cause, Azithromycin, Virus, 2302.22 Farmacología Molecular, chemistry.chemical_compound, 32 Ciencias Médicas, Clarithromycin, medicine, Repurposing, Coronavirus, 2302.21 Biología Molecular, Molecular topology, 12 Matemáticas, business.industry, Topología molecular, COVID-19, Drugs, Lopinavir, chemistry, Fármacos, Brecanavir, business, Tipología molecular, medicine.drug |
| الوصف: | The present communication illustrates the results of a computational study based on molecular topology, focused on the repositioning of drugs to treat the SARS-CoV-2 virus, better known as coronavirus, responsible for the COVID-19 disease. Using lopinavir, a well-known viral protease inhibitor as the reference drug, a mathematical pattern is found allowing the screening of the market drugs, searching for potential candidates to inhibit the said enzyme. This way new possible therapeutic alternatives to fight the coronavirus are found. Results indicate that antivirals such as brecanavir, as well as various groups of drugs, among which are antibiotics of the macrolide family (azithromycin, clarithromycin and erythromycin among others) could be useful in treating COVID-19 infection. Ciencias Experimentales |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aafebb0ffed50112b43fd87e9c76d39e http://hdl.handle.net/20.500.12466/1179 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....aafebb0ffed50112b43fd87e9c76d39e |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |