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Investigation of glial fibrillary acidic protein (GFAP) in body fluids as a potential biomarker for glioma: a systematic review and meta-analysis

التفاصيل البيبلوغرافية
العنوان: Investigation of glial fibrillary acidic protein (GFAP) in body fluids as a potential biomarker for glioma: a systematic review and meta-analysis
المؤلفون: Pierre A. Robe, Elly M. Hol, Jessy V. van Asperen, Daria M. Fedorushkova
المصدر: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 27(1)
سنة النشر: 2021
مصطلحات موضوعية: medicine.medical_specialty, Health, Toxicology and Mutagenesis, Clinical Biochemistry, Intermediate Filaments, Diagnostic tools, Biochemistry, Gastroenterology, Blood serum, Internal medicine, Glioma, Glial Fibrillary Acidic Protein, medicine, Humans, Intermediate filament, Glial fibrillary acidic protein, biology, business.industry, Brain Neoplasms, medicine.disease, Body Fluids, Meta-analysis, Potential biomarkers, biology.protein, Biomarker (medicine), business, Biomarkers
الوصف: INTRODUCTION Liquid biopsies are promising diagnostic tools for glioma. In this quantitative systematic review, we investigate whether the detection of intermediate filaments (IF) in body fluids can be used as a tool for glioma diagnosis and prognosis. MATERIALS AND METHODS We included all studies in which IF-levels were determined in patients with glioma and healthy controls. Of the 28 identified eligible studies, 12 focused on levels of GFAP in serum (sGFAP) and were included for metadata analysis. RESULTS In all studies combined, 62.7% of all grade IV patients had detectable levels of sGFAP compared to 12.7% of healthy controls. sGFAP did not surpass the limit of detection in lower grade patients or healthy controls, but sGFAP was significantly elevated in grade IV glioma (0.12 ng/mL (0.06 - 0.18), P < 0.001) and showed an average median difference of 0.15 ng/mL (0.04 - 0.25, P < 0.01) compared to healthy controls. sGFAP levels were linked to tumour volume, but not to patient outcome. CONCLUSION The presence of sGFAP is indicative of grade IV glioma, but additional studies are necessary to fully determine the usefulness of GFAP in body fluids as a tool for grade IV glioma diagnosis and follow-up.
تدمد: 1366-5804
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaae796074bec47234b1180869434e74
https://pubmed.ncbi.nlm.nih.gov/34844498
Rights: OPEN
رقم الانضمام: edsair.doi.dedup.....aaae796074bec47234b1180869434e74
قاعدة البيانات: OpenAIRE
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