Spinal cord involvement by atrophy and associations with disability are different between multiple sclerosis and neuromyelitis optica spectrum disorder
| العنوان: | Spinal cord involvement by atrophy and associations with disability are different between multiple sclerosis and neuromyelitis optica spectrum disorder |
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| المؤلفون: | Mitsuru Watanabe, Noriko Isobe, Zhiwen Liu, Yuri Nakamura, Takuya Matsushita, Akio Hiwatashi, Jun Ichi Kira, Koji Shinoda, Shotaro Hayashida, Ryo Yamasaki, Shoko Fukumoto, Ayako Sakoda |
| المصدر: | European Journal of Neurology. 27:92-99 |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Multiple Sclerosis, Spinal cord involvement, 03 medical and health sciences, 0302 clinical medicine, Atrophy, Internal medicine, medicine, Humans, Disabled Persons, Spectrum disorder, 030212 general & internal medicine, Aged, Expanded Disability Status Scale, Predictive marker, Neuromyelitis optica, business.industry, Multiple sclerosis, Neuromyelitis Optica, Age Factors, Middle Aged, medicine.disease, Spinal cord, Magnetic Resonance Imaging, Cross-Sectional Studies, medicine.anatomical_structure, Spinal Cord, Neurology, Disease Progression, Female, Neurology (clinical), business, 030217 neurology & neurosurgery |
| الوصف: | BACKGROUND AND PURPOSE The cervical and thoracic cross-sectional spinal cord area (CS-SCA) in multiple sclerosis (MS) correlates with disability, whilst such a correlation remains to be established in neuromyelitis optica spectrum disorder (NMOSD). Our aim was to clarify differences between MS and NMOSD in spinal cord segments where CS-SCA is associated with disability. METHODS The CS-SCA at C2/C3, C3/C4, T8/T9 and T9/T10 vertebral disc levels was measured in 140 MS patients (111 with relapsing-remitting MS and 29 with progressive MS) and 42 NMOSD patients with anti-aquaporin-4 immunoglobulin G. Disability was evaluated by Expanded Disability Status Scale (EDSS) scores. Multivariate associations between CS-SCA and disability were assessed by stepwise forward multiple linear regression. RESULTS Thoracic CS-SCA was significantly smaller in NMOSD patients than in MS patients even after adjusting for age, sex and disease duration (P = 0.002 at T8/T9), whilst there was no difference in cervical CS-SCA between the two diseases. Cervical and thoracic CS-SCA had a negative correlation with EDSS scores in MS patients (P |
| تدمد: | 1468-1331 1351-5101 |
| DOI: | 10.1111/ene.14038 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ea2a86e00cf02d3603df2a9b43eae6 https://doi.org/10.1111/ene.14038 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....a3ea2a86e00cf02d3603df2a9b43eae6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14681331 13515101 |
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| DOI: | 10.1111/ene.14038 |