Intensity of spinal inflammation is associated with radiological structural damage in patients with active axial spondyloarthritis
| العنوان: | Intensity of spinal inflammation is associated with radiological structural damage in patients with active axial spondyloarthritis |
|---|---|
| المؤلفون: | Shirley Chiu Wai Chan, Alexandra Hoi Yan Ng, Eva Tze Fung Chui, Jin Xian Huang, Ho Yin Chung, Kam Ho Lee, Helen Hoi Lun Tsang |
| المصدر: | Rheumatology Advances in Practice |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Multivariate statistics, Radiography, diffusion-weighted imaging, modified Stoke ankylosing spondylitis spine score, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, Bayesian multivariate linear regression, Linear regression, medicine, Back pain, Effective diffusion coefficient, Spondyloarthritis Research Consortium of Canada MRI score, short tau inversion recovery sequence, 030203 arthritis & rheumatology, Ankylosing spondylitis, medicine.diagnostic_test, business.industry, Magnetic resonance imaging, spondyloarthritis, medicine.disease, Original Article, medicine.symptom, business, Nuclear medicine |
| الوصف: | Objective The aim was to investigate the relationship between the intensity of spinal inflammation using the apparent diffusion coefficient (ADC) and radiographic progression in axial SpA. Methods This is a cross-sectional study of participants with axial SpA and back pain. Clinical, biochemical and radiological parameters were collected. The ankylosing spondylitis disease activity score (ASDAS)-CRP was determined. Radiographic progression was represented by the modified Stoke ankylosing spondylitis spine score (mSASSS). MRI with short tau inversion recovery (STIR) and diffusion-weighted imaging sequences were performed simultaneously. Inflammatory lesions on STIR were used for the Spondyloarthritis Research Consortium of Canada (SPARCC) MRI indexes and as references in outlining regions of interest in ADC maps to produce mean (ADCmean) and maximal (ADCmax) ADC values. Univariate and multivariate linear regression analyses were used to determine independent associations between ADC and radiographic progression. Results The 84 participants with identifiable lesions on spinal ADC maps recruited were characterized by a mean (s.d.) age of 45.01 (13.68) years, long disease duration [13.40 (11.01) years] and moderate clinical disease activity [ASDAS-CRP 2.07 (0.83)]. Multivariate regression analysis using ADCmean as the independent variable showed that age (regression coefficient [B] = 0.34; P = 0.01), male sex (B = 0.25; P = 0.04) and ADCmean (B = 0.30; P = 0.01) were positively associated with mSASSS. Multivariate regression analysis using ADCmax as the independent variable showed a tendency for ADCmax to be associated with mSASSS (B = 0.21; P = 0.07). Conclusion The intensity of spinal inflammation as determined by ADC is associated with radiographic progression in participants with active axial SpA. |
| تدمد: | 2514-1775 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a39459f79061cd1e8ccfa51ab8d35fe9 https://pubmed.ncbi.nlm.nih.gov/32016167 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a39459f79061cd1e8ccfa51ab8d35fe9 |
| قاعدة البيانات: | OpenAIRE |
| ResultId |
1 |
|---|---|
| Header |
edsair OpenAIRE edsair.doi.dedup.....a39459f79061cd1e8ccfa51ab8d35fe9 831 3 unknown 830.821655273438 |
| PLink |
https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsair&AN=edsair.doi.dedup.....a39459f79061cd1e8ccfa51ab8d35fe9&custid=s6537998&authtype=sso |
| FullText |
Array
(
[Availability] => 0
)
Array ( [0] => Array ( [Url] => https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a39459f79061cd1e8ccfa51ab8d35fe9# [Name] => EDS - OpenAIRE [Category] => fullText [Text] => View record in OpenAIRE [MouseOverText] => View record in OpenAIRE ) ) |
| Items |
Array
(
[Name] => Title
[Label] => Title
[Group] => Ti
[Data] => Intensity of spinal inflammation is associated with radiological structural damage in patients with active axial spondyloarthritis
)
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Shirley+Chiu+Wai+Chan%22">Shirley Chiu Wai Chan</searchLink><br /><searchLink fieldCode="AR" term="%22Alexandra+Hoi+Yan+Ng%22">Alexandra Hoi Yan Ng</searchLink><br /><searchLink fieldCode="AR" term="%22Eva+Tze+Fung+Chui%22">Eva Tze Fung Chui</searchLink><br /><searchLink fieldCode="AR" term="%22Jin+Xian+Huang%22">Jin Xian Huang</searchLink><br /><searchLink fieldCode="AR" term="%22Ho+Yin+Chung%22">Ho Yin Chung</searchLink><br /><searchLink fieldCode="AR" term="%22Kam+Ho+Lee%22">Kam Ho Lee</searchLink><br /><searchLink fieldCode="AR" term="%22Helen+Hoi+Lun+Tsang%22">Helen Hoi Lun Tsang</searchLink> ) Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => Rheumatology Advances in Practice ) Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2019 ) Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22Multivariate+statistics%22">Multivariate statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Radiography%22">Radiography</searchLink><br /><searchLink fieldCode="DE" term="%22diffusion-weighted+imaging%22">diffusion-weighted imaging</searchLink><br /><searchLink fieldCode="DE" term="%22modified+Stoke+ankylosing+spondylitis+spine+score%22">modified Stoke ankylosing spondylitis spine score</searchLink><br /><searchLink fieldCode="DE" term="%22030218+nuclear+medicine+%26+medical+imaging%22">030218 nuclear medicine & medical imaging</searchLink><br /><searchLink fieldCode="DE" term="%2203+medical+and+health+sciences%22">03 medical and health sciences</searchLink><br /><searchLink fieldCode="DE" term="%220302+clinical+medicine%22">0302 clinical medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Rheumatology%22">Rheumatology</searchLink><br /><searchLink fieldCode="DE" term="%22Bayesian+multivariate+linear+regression%22">Bayesian multivariate linear regression</searchLink><br /><searchLink fieldCode="DE" term="%22Linear+regression%22">Linear regression</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%22">medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Back+pain%22">Back pain</searchLink><br /><searchLink fieldCode="DE" term="%22Effective+diffusion+coefficient%22">Effective diffusion coefficient</searchLink><br /><searchLink fieldCode="DE" term="%22Spondyloarthritis+Research+Consortium+of+Canada+MRI+score%22">Spondyloarthritis Research Consortium of Canada MRI score</searchLink><br /><searchLink fieldCode="DE" term="%22short+tau+inversion+recovery+sequence%22">short tau inversion recovery sequence</searchLink><br /><searchLink fieldCode="DE" term="%22030203+arthritis+%26+rheumatology%22">030203 arthritis & rheumatology</searchLink><br /><searchLink fieldCode="DE" term="%22Ankylosing+spondylitis%22">Ankylosing spondylitis</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%2Ediagnostic%5Ftest%22">medicine.diagnostic_test</searchLink><br /><searchLink fieldCode="DE" term="%22business%2Eindustry%22">business.industry</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22spondyloarthritis%22">spondyloarthritis</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%2Edisease%22">medicine.disease</searchLink><br /><searchLink fieldCode="DE" term="%22Original+Article%22">Original Article</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%2Esymptom%22">medicine.symptom</searchLink><br /><searchLink fieldCode="DE" term="%22business%22">business</searchLink><br /><searchLink fieldCode="DE" term="%22Nuclear+medicine%22">Nuclear medicine</searchLink> ) Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => Objective The aim was to investigate the relationship between the intensity of spinal inflammation using the apparent diffusion coefficient (ADC) and radiographic progression in axial SpA. Methods This is a cross-sectional study of participants with axial SpA and back pain. Clinical, biochemical and radiological parameters were collected. The ankylosing spondylitis disease activity score (ASDAS)-CRP was determined. Radiographic progression was represented by the modified Stoke ankylosing spondylitis spine score (mSASSS). MRI with short tau inversion recovery (STIR) and diffusion-weighted imaging sequences were performed simultaneously. Inflammatory lesions on STIR were used for the Spondyloarthritis Research Consortium of Canada (SPARCC) MRI indexes and as references in outlining regions of interest in ADC maps to produce mean (ADCmean) and maximal (ADCmax) ADC values. Univariate and multivariate linear regression analyses were used to determine independent associations between ADC and radiographic progression. Results The 84 participants with identifiable lesions on spinal ADC maps recruited were characterized by a mean (s.d.) age of 45.01 (13.68) years, long disease duration [13.40 (11.01) years] and moderate clinical disease activity [ASDAS-CRP 2.07 (0.83)]. Multivariate regression analysis using ADCmean as the independent variable showed that age (regression coefficient [B] = 0.34; P = 0.01), male sex (B = 0.25; P = 0.04) and ADCmean (B = 0.30; P = 0.01) were positively associated with mSASSS. Multivariate regression analysis using ADCmax as the independent variable showed a tendency for ADCmax to be associated with mSASSS (B = 0.21; P = 0.07). Conclusion The intensity of spinal inflammation as determined by ADC is associated with radiographic progression in participants with active axial SpA. ) Array ( [Name] => ISSN [Label] => ISSN [Group] => ISSN [Data] => 2514-1775 ) Array ( [Name] => URL [Label] => Access URL [Group] => URL [Data] => <link linkTarget="URL" linkTerm="https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a39459f79061cd1e8ccfa51ab8d35fe9" linkWindow="_blank">https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a39459f79061cd1e8ccfa51ab8d35fe9</link><br /><link linkTarget="URL" linkTerm="https://pubmed.ncbi.nlm.nih.gov/32016167" linkWindow="_blank">https://pubmed.ncbi.nlm.nih.gov/32016167</link> ) Array ( [Name] => Copyright [Label] => Rights [Group] => Cpyrght [Data] => OPEN ) Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsair.doi.dedup.....a39459f79061cd1e8ccfa51ab8d35fe9 ) |
| RecordInfo |
Array
(
[BibEntity] => Array
(
[Languages] => Array
(
[0] => Array
(
[Text] => Undetermined
)
)
[Subjects] => Array
(
[0] => Array
(
[SubjectFull] => Multivariate statistics
[Type] => general
)
[1] => Array
(
[SubjectFull] => Radiography
[Type] => general
)
[2] => Array
(
[SubjectFull] => diffusion-weighted imaging
[Type] => general
)
[3] => Array
(
[SubjectFull] => modified Stoke ankylosing spondylitis spine score
[Type] => general
)
[4] => Array
(
[SubjectFull] => 030218 nuclear medicine & medical imaging
[Type] => general
)
[5] => Array
(
[SubjectFull] => 03 medical and health sciences
[Type] => general
)
[6] => Array
(
[SubjectFull] => 0302 clinical medicine
[Type] => general
)
[7] => Array
(
[SubjectFull] => Rheumatology
[Type] => general
)
[8] => Array
(
[SubjectFull] => Bayesian multivariate linear regression
[Type] => general
)
[9] => Array
(
[SubjectFull] => Linear regression
[Type] => general
)
[10] => Array
(
[SubjectFull] => medicine
[Type] => general
)
[11] => Array
(
[SubjectFull] => Back pain
[Type] => general
)
[12] => Array
(
[SubjectFull] => Effective diffusion coefficient
[Type] => general
)
[13] => Array
(
[SubjectFull] => Spondyloarthritis Research Consortium of Canada MRI score
[Type] => general
)
[14] => Array
(
[SubjectFull] => short tau inversion recovery sequence
[Type] => general
)
[15] => Array
(
[SubjectFull] => 030203 arthritis & rheumatology
[Type] => general
)
[16] => Array
(
[SubjectFull] => Ankylosing spondylitis
[Type] => general
)
[17] => Array
(
[SubjectFull] => medicine.diagnostic_test
[Type] => general
)
[18] => Array
(
[SubjectFull] => business.industry
[Type] => general
)
[19] => Array
(
[SubjectFull] => Magnetic resonance imaging
[Type] => general
)
[20] => Array
(
[SubjectFull] => spondyloarthritis
[Type] => general
)
[21] => Array
(
[SubjectFull] => medicine.disease
[Type] => general
)
[22] => Array
(
[SubjectFull] => Original Article
[Type] => general
)
[23] => Array
(
[SubjectFull] => medicine.symptom
[Type] => general
)
[24] => Array
(
[SubjectFull] => business
[Type] => general
)
[25] => Array
(
[SubjectFull] => Nuclear medicine
[Type] => general
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Intensity of spinal inflammation is associated with radiological structural damage in patients with active axial spondyloarthritis
[Type] => main
)
)
)
[BibRelationships] => Array
(
[HasContributorRelationships] => Array
(
[0] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Shirley Chiu Wai Chan
)
)
)
[1] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Alexandra Hoi Yan Ng
)
)
)
[2] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Eva Tze Fung Chui
)
)
)
[3] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Jin Xian Huang
)
)
)
[4] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Ho Yin Chung
)
)
)
[5] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Kam Ho Lee
)
)
)
[6] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Helen Hoi Lun Tsang
)
)
)
)
[IsPartOfRelationships] => Array
(
[0] => Array
(
[BibEntity] => Array
(
[Dates] => Array
(
[0] => Array
(
[D] => 07
[M] => 11
[Type] => published
[Y] => 2019
)
)
[Identifiers] => Array
(
[0] => Array
(
[Type] => issn-print
[Value] => 25141775
)
[1] => Array
(
[Type] => issn-locals
[Value] => edsair
)
[2] => Array
(
[Type] => issn-locals
[Value] => edsairFT
)
)
[Numbering] => Array
(
[0] => Array
(
[Type] => volume
[Value] => 4
)
[1] => Array
(
[Type] => issue
[Value] => 1
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Rheumatology advances in practice
[Type] => main
)
)
)
)
)
)
)
|
| IllustrationInfo |