Mechanism of colchicine impairment on learning and memory, and protective effect of CGP36742 in mice
| العنوان: | Mechanism of colchicine impairment on learning and memory, and protective effect of CGP36742 in mice |
|---|---|
| المؤلفون: | ZaiFang Yu, BenRong Hu, GuanJun Cheng |
| المصدر: | Brain Research. 750:53-58 |
| بيانات النشر: | Elsevier BV, 1997. |
| سنة النشر: | 1997 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Synaptic Membranes, Glutamic Acid, Hippocampus, GABAB receptor, Hippocampal formation, GABA Antagonists, Mice, Radioligand Assay, chemistry.chemical_compound, Organophosphorus Compounds, Memory, Internal medicine, Avoidance Learning, Reaction Time, medicine, Animals, Colchicine, Memory impairment, Infusions, Parenteral, Molecular Biology, gamma-Aminobutyric Acid, Cerebral Cortex, Neurons, Electroshock, General Neuroscience, Glutamate receptor, Antagonist, Cortex (botany), Neuroprotective Agents, Endocrinology, Receptors, GABA-B, nervous system, chemistry, Neurology (clinical), Psychology, Developmental Biology |
| الوصف: | Fourteen days after hippocampal microinfusion with colchicine (COL), learning and memory ability of mice was significantly impaired, while glutamate (Glu), γ-aminobutyric acid (GABA), Glu/GABA and GABAB receptor levels in the cortex and/or the hippocampus were significantly changed. After treatment with a GABAB receptor antagonist, CGP36742, learning and memory impairment caused by COL could be significantly improved, and the above indices in brain regions reversed. These results suggest GABAB antagonists may have therapeutic value in the treatment of Alzheimer's disease. ©1997 Elsevier Science B.V. All rights reserved. |
| تدمد: | 0006-8993 |
| DOI: | 10.1016/s0006-8993(96)01158-4 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0905b400a69fc75e0e3aee60727c8f6 https://doi.org/10.1016/s0006-8993(96)01158-4 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....a0905b400a69fc75e0e3aee60727c8f6 |
| قاعدة البيانات: | OpenAIRE |
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