The utility of DNA methylation analysis in elderly patients with pilocytic astrocytoma morphology
| العنوان: | The utility of DNA methylation analysis in elderly patients with pilocytic astrocytoma morphology |
|---|---|
| المؤلفون: | Yasuki Suruga, Kaishi Satomi, Yoshihiro Otani, Kentaro Fujii, Joji Ishida, Atsuhito Uneda, Nobushige Tsuboi, Keigo Makino, Shuichiro Hirano, Naoya Kemmotsu, Ryoji Imoto, Ryo Mizuta, Yusuke Tomita, Takao Yasuhara, Kana Washio, Hiroyuki Yanai, Yuko Matsushita, Yuko Hibiya, Akihiko Yoshida, David Capper, Koichi Ichimura, Isao Date |
| المصدر: | Journal of neuro-oncology. 160(1) |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Adult, Aged, 80 and over, Cancer Research, Adolescent, Brain Neoplasms, Middle Aged, DNA Methylation, Astrocytoma, Isocitrate Dehydrogenase, Young Adult, Neurology, Oncology, Child, Preschool, Mutation, Humans, Neurology (clinical), Child, Aged, Retrospective Studies |
| الوصف: | Pilocytic astrocytoma (PA) is a circumscribed low-grade astrocytic glioma, generally considered to be associated with a good prognosis. However, a subset of PA patients shows unfavorable outcomes. In this study, we retrospectively reviewed PA patients and performed further molecular analysis, such as DNA methylation profiling, to identify prognostic factors.We analyzed 29 histologically-confirmed PA patients from a single center from 2002 to 2021 and conducted integrated molecular analyses among elderly PA patients since age was an independent prognostic factor for poor outcomes.The median age at diagnosis was 14 years (range 3-82 years) and 4 patients (14%) were elderly (patients ≥ 60 years old). Age over 60 was associated with poor progression-free survival and overall survival. We performed DNA methylation analysis on 2 of the 4 elderly patients. Both cases were histologically diagnosed as PA, but DNA methylation profiling revealed one as high-grade astrocytoma with piloid features (all methylation class scores were below 0.3 in both v11b4 and v12.5) and the other as glioblastoma, IDH-wildtype (score was over 0.5 in both v11b4 and v12.5), using the German Cancer Research Center methylation profiling classifiers and t-SNE analysis.Elderly patients with PA morphology showed unfavorable outcomes in this cohort. In those patients, further molecular analysis and DNA methylation profiling revealed the possibility of high-grade astrocytic tumors, including newly defined entities. |
| تدمد: | 1573-7373 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e75e2e79e5c18d088a4f7e6d6d6bc27 https://pubmed.ncbi.nlm.nih.gov/36107362 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....9e75e2e79e5c18d088a4f7e6d6d6bc27 |
| قاعدة البيانات: | OpenAIRE |
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