Derivatization of Amino Acids and Peptides via Photoredox-Mediated Conjugate Addition
| العنوان: | Derivatization of Amino Acids and Peptides via Photoredox-Mediated Conjugate Addition |
|---|---|
| المؤلفون: | Jeffrey W. Schubert, Olivia Zhang |
| المصدر: | The Journal of Organic Chemistry. 85:6225-6232 |
| بيانات النشر: | American Chemical Society (ACS), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | chemistry.chemical_classification, 010405 organic chemistry, Chemistry, Organic Chemistry, Structural diversity, Tripeptide, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, 0104 chemical sciences, Amino acid, chemistry.chemical_compound, Dehydroalanine, Amines, Amino Acids, Peptides, Derivatization, Oxidation-Reduction, Conjugate |
| الوصف: | Unnatural amino acids are key building blocks in therapeutically relevant peptides. Thus, the development of novel methods to increase the structural diversity of the unnatural amino acid pool is needed. Herein, a photoredox-mediated decarboxylative radical conjugate addition to dehydroalanine derivatives is disclosed. Mild, robust, and general conditions were identified and applied to the diastereoselective synthesis of unnatural amino acids and the late-stage derivatization of a tripeptide. |
| تدمد: | 1520-6904 0022-3263 |
| DOI: | 10.1021/acs.joc.0c00635 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bbebae948e761e2c1332b082fd66d71 https://doi.org/10.1021/acs.joc.0c00635 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....9bbebae948e761e2c1332b082fd66d71 |
| قاعدة البيانات: | OpenAIRE |
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