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Reduced Socs3 expression in adipose tissue protects female mice against obesity-induced insulin resistance

التفاصيل البيبلوغرافية
العنوان: Reduced Socs3 expression in adipose tissue protects female mice against obesity-induced insulin resistance
المؤلفون: Sebastian Beck Jørgensen, Sandra Galic, Jane Honeyman, Rengasamy Palanivel, Gregory R. Steinberg, Kimberly A. Hewitt, Morgan D. Fullerton
المصدر: Diabetologia. 55:3083-3093
بيانات النشر: Springer Science and Business Media LLC, 2012.
سنة النشر: 2012
مصطلحات موضوعية: Blood Glucose, Male, medicine.medical_specialty, FGF21, Endocrinology, Diabetes and Metabolism, Adipose tissue, Suppressor of Cytokine Signaling Proteins, Article, Mice, 03 medical and health sciences, Oxygen Consumption, Sex Factors, 0302 clinical medicine, Insulin resistance, Internal medicine, Insulin receptor substrate, Glucose Intolerance, Internal Medicine, Animals, Insulin, Medicine, Obesity, SOCS3, Phosphorylation, SOCS2, 030304 developmental biology, Inflammation, Mice, Knockout, 0303 health sciences, business.industry, Suppressor of cytokine signaling 1, Leptin, medicine.disease, Dietary Fats, Mice, Inbred C57BL, Endocrinology, Adipose Tissue, Suppressor of Cytokine Signaling 3 Protein, 030220 oncology & carcinogenesis, Insulin Receptor Substrate Proteins, Female, Insulin Resistance, Energy Metabolism, business
الوصف: Inflammation in obesity increases the levels of the suppressor of cytokine signalling-3 (SOCS3) protein in adipose tissue, but the physiological importance of this protein in regulating whole-body insulin sensitivity in obesity is not known.We generated Socs3 floxed (wild-type, WT) and Socs3 aP2 (also known as Fabp4)-Cre null (Socs3 AKO) mice. Mice were maintained on either a regular chow or a high-fat diet (HFD) for 16 weeks during which time body mass, adiposity, glucose homeostasis and insulin sensitivity were assessed.The HFD increased SOCS3 levels in adipose tissue of WT but not Socs3 AKO mice. WT and Socs3 AKO mice had similar body mass and adiposity, assessed using computed tomography (CT) imaging, irrespective of diet or sex. On a control chow diet there were no differences in insulin sensitivity or glucose tolerance. When fed a HFD, female but not male Socs3 AKO mice had improved glucose tolerance as well as lower fasting glucose and insulin levels compared with WT littermates. Hyperinsulinaemic-euglycaemic clamps and positron emission tomography (PET) imaging demonstrated that improved insulin sensitivity was due to elevated adipose tissue glucose uptake. Increased insulin-stimulated glucose uptake in adipose tissue was associated with enhanced levels and activating phosphorylation of insulin receptor substrate-1 (IRS1).These data demonstrate that inhibiting SOCS3 production in adipose tissue of female mice is effective for improving whole-body insulin sensitivity in obesity.
تدمد: 1432-0428
0012-186X
DOI: 10.1007/s00125-012-2665-3
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99a6526d3c309418af970d7e2b1d3076
https://doi.org/10.1007/s00125-012-2665-3
Rights: OPEN
رقم الانضمام: edsair.doi.dedup.....99a6526d3c309418af970d7e2b1d3076
قاعدة البيانات: OpenAIRE
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