أعرض في EDS

A genomic storm in critically injured humans

التفاصيل البيبلوغرافية
العنوان: A genomic storm in critically injured humans
المؤلفون: Michael West, S. Lowry, J. Sperry, Celeste C. Finnerty, J. Cuschieri, P. Mason, Daniel G. Remick, Shaw Warren, Michael N. Mindrinos, L. Moldawer, Henry V. Baker, Grace P. McDonald-Smith, Lily L. Altstein, B. Brownstein, Philip H. Mason, H. Baker, T. Billiar, R. Tompkins, M. Jeschke, Jeffrey L. Johnson, Ronald W. Davis, Mehmet Toner, Doug Hayden, Wing Hung Wong, Douglas L. Hayden, Richard L. Gamelli, David G. Camp, Yuping Zhang, Richard D. Smith, Nicole S. Gibran, D. Herndon, Roger J. Davis, John D. Storey, Alex G. Cuenca, Ronald V. Maier, David A. Schoenfeld, Jason L. Sperry, M. Lopez, A. Nathens, Joseph P. Minei, J. Seok, Ulysses J. Balis, J. P. Cobb, M. Klein, David N. Herndon, Wenzhong Xiao, G. McDonald-Smith, Paul E. Bankey, Joseph Cuschieri, Bruce A. McKinley, J. Minei, Marc G. Jeschke, N. Gibran, Bram Wispelwey, Steven E. Calvano, Timothy R. Billiar, Laura Hennessy, D. Schoenfeld, L. Hennessy, A. Cuenca, J. Storey, Junhee Seok, H. Shaw Warren, J. Perren Cobb, K. De Asit, Matthew B. Klein, R. Gamelli, R. Maier, P. Bankey, Michael B. Shapiro, Grant E. O'Keefe, Carol L. Miller-Graziano, M. Cecilia Lopez, Avery B. Nathens, M. Mindrinos, Hong Gao, Bernard H. Brownstein, S. Calvano, Shari Honari, Ronald G. Tompkins, C. Finnerty, Ernest E. Moore, E. Moore, Lyle L. Moldawer, J. Johnson, M. West, Robert Tibshirani, Laurence G. Rahme, Weihong Xu, Brett D. Arnoldo, Frederick A. Moore, H. Gao, Stephen F. Lowry, B. Arnoldo, W. Xiao, Brian G. Harbrecht
المصدر: The Journal of Experimental Medicine
بيانات النشر: Rockefeller University Press, 2011.
سنة النشر: 2011
مصطلحات موضوعية: Adult, Male, Transcription, Genetic, Critical Illness, animal diseases, Immunology, Inflammation, Adaptive Immunity, Biology, Transcriptome, 03 medical and health sciences, 0302 clinical medicine, Immune system, Immunity, Leukocytes, medicine, Humans, Immunology and Allergy, skin and connective tissue diseases, 030304 developmental biology, Regulation of gene expression, 0303 health sciences, Trauma Severity Indices, Innate immune system, Genome, Human, Brief Definitive Report, 030208 emergency & critical care medicine, biochemical phenomena, metabolism, and nutrition, Acquired immune system, Immunity, Innate, Endotoxins, Gene Expression Regulation, Blunt trauma, Female, sense organs, medicine.symptom, Burns
الوصف: Critical injury in humans induces a genomic storm with simultaneous changes in expression of innate and adaptive immunity genes.
Human survival from injury requires an appropriate inflammatory and immune response. We describe the circulating leukocyte transcriptome after severe trauma and burn injury, as well as in healthy subjects receiving low-dose bacterial endotoxin, and show that these severe stresses produce a global reprioritization affecting >80% of the cellular functions and pathways, a truly unexpected “genomic storm.” In severe blunt trauma, the early leukocyte genomic response is consistent with simultaneously increased expression of genes involved in the systemic inflammatory, innate immune, and compensatory antiinflammatory responses, as well as in the suppression of genes involved in adaptive immunity. Furthermore, complications like nosocomial infections and organ failure are not associated with any genomic evidence of a second hit and differ only in the magnitude and duration of this genomic reprioritization. The similarities in gene expression patterns between different injuries reveal an apparently fundamental human response to severe inflammatory stress, with genomic signatures that are surprisingly far more common than different. Based on these transcriptional data, we propose a new paradigm for the human immunological response to severe injury.
تدمد: 1540-9538
0022-1007
DOI: 10.1084/jem.20111354
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9791ea55ca1348aadb4e375e9da8246a
https://doi.org/10.1084/jem.20111354
Rights: OPEN
رقم الانضمام: edsair.doi.dedup.....9791ea55ca1348aadb4e375e9da8246a
قاعدة البيانات: OpenAIRE
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IllustrationInfo